PMID: 9188606Jul 1, 1997Paper

Theiler's virus and Mengo virus induce cross-reactive cytotoxic T lymphocytes restricted to the same immunodominant VP2 epitope in C57BL/6 mice

Journal of Virology
S DethlefsE L Larsson-Sciard

Abstract

C57BL/6 mice develop a virus-specific cytotoxic T-lymphocyte (CTL) response after intraperitoneal inoculation with either the DA strain of Theiler's virus or Mengo virus, two members of the Cardiovirus genus. These CTLs contribute to viral clearance in the case of Theiler's virus but do not protect the mice from the fatal encephalomyelitis caused by Mengo virus. In this study we show that DA and Mengo virus-induced CTLs are cross-reactive. The cross-reactivity is due to a conserved, H-2Db-restricted epitope located between amino acid residues 122 and 130 of the VP2 capsid protein (VP2(122-130)). This epitope is immunodominant in C57BL/6 mice infected with Theiler's virus. The VP2(122-130) epitope, initially identified for Mengo virus, is the first CTL epitope described for Theiler's virus.

References

Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·M LuoH L Lipton
Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R A GrantJ M Hogle
Mar 1, 1986·The Journal of Experimental Medicine·M RodriguezC S David
Jul 1, 1985·Mayo Clinic Proceedings·M Rodriguez
Apr 1, 1965·Journal of Cellular Physiology·J S ColterL R Hatch
Aug 1, 1995·The Journal of General Virology·N EscriouS van der Werf
Jan 1, 1995·Immunogenetics·H G RammenseeS Stevanoviíc
Jun 1, 1994·The Journal of Experimental Medicine·L K SelinR M Welsh
Jan 1, 1993·Journal of Virology·L FietteC P Rossi

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Citations

Jan 17, 2004·Clinical Microbiology Reviews·Emilia L OleszakChris D Platsoucas
Nov 7, 2009·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Ikuo Tsunoda, Robert S Fujinami
Feb 13, 2016·Journal of Virology·Autumn J RuizStephen J Russell
Aug 2, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zachariah P TritzAaron J Johnson
Mar 4, 2000·International Immunology·K M DrescherM Rodriguez
May 24, 2000·Journal of Virology·A Azoulay-CaylaJ F Bureau
Sep 13, 2005·Annual Review of Microbiology·Michel BrahicThomas Michiels
Jan 7, 1998·Immunological Reviews·P MonteyneM Brahic
Aug 18, 2010·Cellular and Molecular Life Sciences : CMLS·Tanja ScheiklRoland S Liblau
May 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aaron J JohnsonLarry R Pease
Sep 26, 2008·Journal of Virology·Zhiguo LiangHoward L Lipton
Mar 10, 2016·The Journal of General Virology·Frédéric SorgeloosThomas Michiels
Apr 29, 1998·Journal of Virology·C P RossiM Brahic
Oct 22, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M Brahic, J F Bureau
Jul 9, 2008·Journal of Neuroinflammation·Istvan PirkoAaron J Johnson

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