Theophylline impairs memory/learning in developing mice

Brain & Development
Mieko HiroseKazuie Iinuma

Abstract

We studied the relationship between theophylline and memory/learning using an elevated plus-maze test and measuring spontaneous locomotor activity in developing mice. There were no significant differences in transfer latency (TL) in 21-, 30- and 42-day-old mice in the acquisition trial, but theophylline significantly prolonged TL in comparison with the control group in 21- and 30-day-old mice in the retention trial (n = 20; 21-day-old mice, P = 0.0009; 30-day-old mice, P = 0.03). The dose-dependent stimulant effects of theophylline were shown in spontaneous locomotor activity (n = 16; 21-day-old mice, P = 0.0005; 30-day-old mice, P = 0.0007; 42-day-old mice, P = 0.0003) in all groups and in rearing in 21-day-old mice (P = 0.02) 1 h after drug administration, but there were no significant effects 24 h after drug administration in all groups. Our study showed that even a therapeutic dose of theophylline impaired memory/learning only in developing mice, and theophylline increased locomotor activity both in developing and adolescent mice. These observations are consistent with several clinical studies, which reported the relationships between theophylline use and memory/learning and learning-related behaviors in children, such as d...Continue Reading

References

Mar 14, 1979·Psychopharmacology·J A IzquierdoG Rabiller
Jan 15, 1978·European Journal of Pharmacology·D P Cardinali
Mar 1, 1989·American Journal of Diseases of Children·L RappaportF Twarog
Jan 1, 1988·The Journal of Allergy and Clinical Immunology·C T FurukawaC W Bierman
Sep 1, 1986·The Journal of Pediatrics·M D Baker
Jul 1, 1985·The Journal of Allergy and Clinical Immunology·C SpringerS Godfrey
Aug 1, 1981·Annals of Internal Medicine·W G WasserB K Richardson
Dec 1, 1995·Psychopharmacology·M R ZarrindastB Shafaghi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Douglas S Kim, Richard D Palmiter
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Walter AdrianiG Laviola
© 2021 Meta ULC. All rights reserved