Abstract
Although theophylline has been used in the treatment of asthma for decades, it is not a first line choice any more. It is a well-known bronchodilator, but was recently discovered also to be an anti-inflammatory, immunomodulatory and bronchoprotective agent. Therefore we wanted to establish the role of theophylline on prostaglandin and leukotriene production, which plays a part in the pathogenesis of asthma. Theophylline was infused (bolus 5 mg/kg in 15 min and infusion 0.4 mg/kg/h for 1 h 45 min) into healthy volunteers. Thromboxane B2, prostaglandin E2 and leukotriene E4 were measured from the A23187-stimulated whole blood samples and stable metabolites of thromboxane A2; prostacyclin and leukotriene E4 were measured from urine. Theophylline increased prostaglandin E2 production and decreased leukotriene E4 production ex vivo in whole blood, thus increasing the prostanoid/leukotriene ratio. It did not change thromboxane B2 production stimulated by either spontaneous clotting or A23187 in the whole blood. Theophylline had hardly any effect on in vivo thromboxane, prostacyclin and leukotriene E4 production measured as urinary metabolites, 11-dehydro-thromboxane B2, 2,3-dinor-6-keto-prostaglandin F1alpha and leukotriene E4, respe...Continue Reading
References
Jun 15, 1990·Biochemical Pharmacology·L E BrackettJ W Daly
Feb 1, 1989·The Journal of Allergy and Clinical Immunology·R A Pauwels
Oct 1, 1987·The American Review of Respiratory Disease·J M Drazen, K F Austen
Aug 1, 1987·Prostaglandins·M DamonP Godard
Oct 1, 1986·The Journal of Allergy and Clinical Immunology·C G Persson
Mar 1, 1968·Archives of Internal Medicine·J Koch-Weser
Dec 4, 1980·Nature·S E DahlénB Samuelsson
Jan 1, 1983·Circulation·R E VestalJ B Halter
Nov 30, 1981·Biochemical and Biophysical Research Communications·S S Yen, H G Morris
Aug 1, 1982·The Journal of Allergy and Clinical Immunology·P GodardF B Michel
Jul 1, 1995·Naunyn-Schmiedeberg's Archives of Pharmacology·A RiuttaH Vapaatalo
Jun 1, 1995·American Journal of Respiratory and Critical Care Medicine·V LagenteI Moodley
Jul 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·T KerttulaJ Alanko
Jul 1, 1994·Prostaglandins·A RiuttaJ Alanko
Jun 1, 1996·The Journal of Allergy and Clinical Immunology·M KraftR J Martin
Jan 10, 1948·British Medical Journal·Z Z GODLOWSKI
Citations
Nov 11, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Andrew A WhiteRonald A Simon
Jan 16, 1999·Journal of Cardiovascular Pharmacology·T KerttulaS Kaukinen
Dec 23, 2003·Cephalalgia : an International Journal of Headache·R FischerR M Huber
Feb 1, 2000·Respiratory Medicine·H TanakaS Abe
Nov 18, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Pedro Araujo, Livar Frøyland