Theophylline infusion modulates prostaglandin and leukotriene production in man

Prostaglandins, Leukotrienes, and Essential Fatty Acids
T KerttulaJ Alanko

Abstract

Although theophylline has been used in the treatment of asthma for decades, it is not a first line choice any more. It is a well-known bronchodilator, but was recently discovered also to be an anti-inflammatory, immunomodulatory and bronchoprotective agent. Therefore we wanted to establish the role of theophylline on prostaglandin and leukotriene production, which plays a part in the pathogenesis of asthma. Theophylline was infused (bolus 5 mg/kg in 15 min and infusion 0.4 mg/kg/h for 1 h 45 min) into healthy volunteers. Thromboxane B2, prostaglandin E2 and leukotriene E4 were measured from the A23187-stimulated whole blood samples and stable metabolites of thromboxane A2; prostacyclin and leukotriene E4 were measured from urine. Theophylline increased prostaglandin E2 production and decreased leukotriene E4 production ex vivo in whole blood, thus increasing the prostanoid/leukotriene ratio. It did not change thromboxane B2 production stimulated by either spontaneous clotting or A23187 in the whole blood. Theophylline had hardly any effect on in vivo thromboxane, prostacyclin and leukotriene E4 production measured as urinary metabolites, 11-dehydro-thromboxane B2, 2,3-dinor-6-keto-prostaglandin F1alpha and leukotriene E4, respe...Continue Reading

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Citations

Nov 11, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Andrew A WhiteRonald A Simon
Jan 16, 1999·Journal of Cardiovascular Pharmacology·T KerttulaS Kaukinen
Dec 23, 2003·Cephalalgia : an International Journal of Headache·R FischerR M Huber
Nov 18, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Pedro Araujo, Livar Frøyland

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