Theophylline suppresses the release of interleukin-4 by peripheral blood mononuclear cells

International Archives of Allergy and Immunology
Y TohdaS Nakajima

Abstract

To elucidate the mechanism of the anti-inflammatory effect of theophylline, peripheral blood mononuclear cells (PBMCs) collected from patients with bronchial asthma who had a RAST score for Dermatophagoides farinae (Df) > = 3 were stimulated with Df antigen, and the interleukin-4 (IL-4) production by the stimulated PBMCs was determined in the presence and absence of theophylline. The stimulated IL-4 production in the PBMCs was significantly suppressed by simultaneous treatment with theophylline (8 microg/ml). Furthermore, the intracellular 3',5'-adenosine monophosphate (cAMP) level following stimulation with Df was significantly higher in PBMCs simultaneously treated with theophylline (8 microg/ml) than in nontreated controls. These results suggest that theophylline suppresses the IL-4 production in inflammatory cells by increasing the intracellular cAMP level; this effect may thus provide an additional basis for the benefit of theophylline in antiasthmatic therapy.

Citations

Jun 1, 2002·Obstetrics and Gynecology·Yoshio YoneyamaTsutomu Araki
Apr 18, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yasuko Kiyokawa, Yoshio Yoneyama
Mar 30, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Masoumeh Ghasemi-PirbalutiMohammad Javad Hosseini
Jan 24, 2002·The Journal of International Medical Research·Y TohdaS Nakajima

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