PMID: 9189828Jun 15, 1997Paper

Theoretical analysis of hydrolysis of polydimethylsiloxane (PDMS)

Journal of Biomedical Materials Research
J K West

Abstract

Silicones (polydimethylsiloxane, PDMS) are the materials currently used in most breast implants. ICP and FTIR analysis of the tissue capsule around aged breast implants and in vitro models show that Si-containing material is leaking from the PDMS implants. In this study, the hydrolysis of PDMS has been theoretically modeled using a semiempirical quantum mechanical method called AM1. The activation barrier for removing a methanol monomer was found to be +82 Kcal/mol while the removal of a methane monomer was +41 Kcal/mol. Using the same AM1 method, hydrolysis of the identical to Si-O-Si identical to bond also has been modeled for pentasilicic acid and, in this study, for 1,1,3,3,-fetramethyldisiloxane-1,3-diol. The barrier to the removal of a silicon-containing tetrahedron for both studies was found to be +27 Kcal/mol. This is approximately one and a half times smaller than the energy of that needed to remove a methyl group. The pentacoordinated silicon-activated transition state for hydrolysis of PDMS may provide an energetically favorable pathway for development of a surface that will enhance chemisorption of charged protein molecules, and such a pathway may show up in NMR studies of the hydrolysis of PDMS.

References

Jun 1, 1988·The American Journal of Surgical Pathology·L D TruongD Woznicki
Nov 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B PfleidererL Garrido
Jun 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·L GarridoJ L Ackerman

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Citations

Aug 3, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Simon BrunnerSusanne Binder
Feb 19, 2005·Electrophoresis·Yulia MourzinaAndreas Offenhäusser
Dec 17, 2014·Chemical Reviews·Christoph Rücker, Klaus Kümmerer

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