PMID: 9525065Apr 3, 1998Paper

Theoretical and clinical significance of neuroplasticity

Bratislavské lekárske listy
S Trojan, J Pokorný

Abstract

Plasticity is a specific feature of the nervous system, characterized by two basic phenomena: The first type of "functional plasticity" develops comparatively quickly, brings about mainly functional changes and is usually reversible. The second type has the features of an adaptation and affects the expression of genotype into phenotype. Neuroplastic mechanisms are triggered by various natural or artificial stimuli which may differ quantitatively (they arise in the internal or external environment) or qualitatively. Neuroplastic mechanisms are based on modulation of the signal transmission over synapses (e.g., the transmitter release, activity of postsynaptic receptors, efficiency changes in the transmission in the postsynaptic segment). They can be related to the interneuronal relations changes (e.g., number of certain types of synapses, significance of the wiring of different elements of the neuronal circuits). Resulting changes may occur in the communication between neurons (synaptic level), in the activity of the local neuronal circuits (level of local circuits) or in the relations between individual functional brain systems (multimodular level). Neuroplasticity might be based on structural changes which can be revealed by m...Continue Reading

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