Theoretical and experimental evaluation of the low m/z transmission of an electrodynamic ion funnel

Journal of the American Society for Mass Spectrometry
Jason S PageRichard D Smith

Abstract

The transmission of ions at low m/z can often be either necessary for an application or problematic (e.g., when large numbers of low m/z ions consume a large fraction of an ion trap's capacity). The low m/z ion transmission limit of an electrodynamic ion funnel has been characterized using both experimental and theoretical approaches. A theoretical model is developed based on a series of infinite wire conductors that represent the ring electrodes of the ion funnel. Mathematical relationships for both low and high m/z cutoffs of the idealized two-dimensional system are derived. The low m/z cutoff is also evaluated through a series of experiments that show it is influenced by both the RF frequency and the DC electric field gradient. However, unlike multipole ion guides, there is no marked dependence of the low m/z cutoff on the RF amplitude, in agreement with theoretical results. With this new understanding, ion funnels can be designed and configured to better match the m/z range requirements for various applications.

References

May 1, 1990·Analytical Chemistry·R D SmithH R Udseth
Jun 14, 2000·Analytical Chemistry·T KimR D Smith
Jan 11, 2000·Rapid Communications in Mass Spectrometry : RCM·E C LynnC C Han
May 9, 2002·Mass Spectrometry Reviews·N B Cech, C G Enke
Sep 24, 2004·Rapid Communications in Mass Spectrometry : RCM·Kevin GilesRobert H Bateman
Feb 8, 2005·Journal of the American Society for Mass Spectrometry·Jason S PageRichard D Smith
Aug 30, 2005·Journal of Mass Spectrometry : JMS·Jason S PageRichard D Smith

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Citations

Jul 14, 2007·Journal of the American Society for Mass Spectrometry·Jason S PageRichard D Smith
Oct 10, 2009·Journal of the American Society for Mass Spectrometry·Jason S PageRichard D Smith
Sep 14, 2007·Analytical Chemistry·Yehia IbrahimRichard D Smith
Oct 30, 2010·Analytical Chemistry·Ioan MargineanRichard D Smith
Aug 26, 2010·Molecular & Cellular Proteomics : MCP·Joseph N BrownRichard D Smith
Aug 7, 2010·The Review of Scientific Instruments·Annette SvendsenThomas R Rizzo
Aug 12, 2014·Omics : a Journal of Integrative Biology·Rémi LonguespéeEdwin De Pauw
Apr 25, 2009·Mass Spectrometry Reviews·Ryan T KellyRichard D Smith
Mar 24, 2016·Rapid Communications in Mass Spectrometry : RCM·Hualei XuDi Tian
Aug 6, 2015·Journal of the American Society for Mass Spectrometry·Sergey GimelsheinEugene Moskovets
Jun 6, 2015·Rapid Communications in Mass Spectrometry : RCM·Quan YuXiaohao Wang
Aug 20, 2016·Rapid Communications in Mass Spectrometry : RCM·Fang Yuan GaoQing He Zhang
Jun 5, 2014·European Journal of Mass Spectrometry·Petr JurcicekHongbin Xiao
Jan 3, 2007·Journal of Mass Spectrometry : JMS
May 30, 2019·Journal of the American Society for Mass Spectrometry·Florian SchlottmannStefan Zimmermann
Apr 9, 2019·Analytical and Bioanalytical Chemistry·Ansgar T KirkStefan Zimmermann
Aug 12, 2020·Rapid Communications in Mass Spectrometry : RCM·Shao ZhouJiancheng Yu
Mar 9, 2013·Chemical Society Reviews·Mathivathani Kandiah, Pawel L Urban
Aug 3, 2018·The Review of Scientific Instruments·N de RuetteH Cederquist
Aug 26, 2014·Analytical Chemistry·Aleksey V TolmachevRichard D Smith
Feb 15, 2018·Analytical Chemistry·Boone M PrenticeJeffrey M Spraggins

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