PMID: 8602677Feb 1, 1996Paper

Theoretical assessment of normobaric oxygen therapy to treat pneumocephalus

Anesthesiology
F Dexter, D K Reasoner

Abstract

Pneumocephalus has been linked to several clinical conditions, including headache, lethargy, and even brain herniation or death. The effects of different normobaric oxygen concentrations and durations of therapy on the rate of air absorption were examined. An existing mathematical model of inert gas absorption was used. The model accounts for the major phenomena that determine absorption of bubbles, including surface tension, pressure dependence of bubble size, and removal of gases to the surrounding tissue. Sensitivity analysis tested reliability of our results. Times for a 50-ml air collection to have been absorbed were 5.8, 1.9, and 0.6 weeks at an FIO2 of 0.21, 0.4, and 1.0 respectively. Thirty percent and 72% of the air was absorbed in 2 days at an FIO2 of 0.4 and 1.0, respectively. The percent decrease in time for absorption achieved by increasing the FIO2 from 0.21 was nearly identical for different volumes of air. The benefit of increasing the FIO2 decreased with progressive increases in the FIO2. Increasing the FIO2 from 0.21 to 0.4 caused the time to total air absorption to decrease by 67%. In contrast, increasing the FIO2 from 0.8 to 1.0 caused the time to total air absorption to decrease by an additional 3%. Based o...Continue Reading

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Citations

Jun 14, 2013·Case Reports in Emergency Medicine·Shin AhnKyung Soo Lim
Aug 28, 2002·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·W J Becker
Oct 5, 2006·Obstetrics and Gynecology·Loren SmarkuskyVíctor Hugo González-Quintero
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May 2, 2008·Journal of Neurosurgery·Pankaj A GorePeter Nakaji
Feb 28, 2009·Journal of Neurosurgery·Matthew Quigley
Feb 15, 2013·The American Journal of the Medical Sciences·Cherie W ChungRagheb Assaly
Apr 17, 2012·The Journal of Emergency Medicine·Joshua Simmons, Andrew M Luks
Apr 20, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Giyas AyberkMehmet Faik Ozveren
May 16, 2009·Diagnostic Microbiology and Infectious Disease·Chin-Chi KuoJuey-Jen Hwang
Jul 2, 2016·Asian Journal of Neurosurgery·Erhan ÇelikoğluAli Fatih Ramazanoğlu
Mar 17, 2015·A & a Case Reports·Elif CingiRichard Prielipp
Jul 7, 2016·The Journal of Emergency Medicine·Aakash Kaushik ShahJames Kimo Takayesu
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Sep 12, 2014·F1000Research·Beatriz Nistal-Nuño, Manuel Ángel Gómez-Ríos
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