Theoretical considerations in the dynamic closed-loop baroreflex and autoregulatory control of total peripheral resistance

American Journal of Physiology. Heart and Circulatory Physiology
Nikolai Aljuri, R J Cohen

Abstract

The most important goal of this study is to enhance our understanding of the crucial functional relationships that determine the behavior of the systemic circulation and its underlying physiological regulatory mechanisms with minimal modeling. To the present day, much has been said about the indirect hydraulic effects of right atrial pressure (PRA) via cardiac output (CO) on arterial pressure (Pa) through the heart and pulmonary circulation or the direct regulatory effects of PRA on Pa through the cardiopulmonary baroreflex; however, very little attention has been given to the hydraulic influence that PRA exerts directly through the systemic circulation. The experimental data reported by Guyton et al. in 1957 demonstrated that steady-state PRA and the rate at which blood passes through the systemic circulation are locked in a functional relationship independent of any consequence of altered PRA on cardiac function. With this in mind, we emphasize the analytic algebraic analysis of the systemic circulation composed of arteries, veins, and its underlying physiological regulatory mechanisms of baroreflex and autoregulatory modulation of total peripheral resistance (TPR), where the behavior of the system can be analytically synthes...Continue Reading

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Jul 3, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Nikolai AljuriRichard J Cohen

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Citations

May 11, 2011·Theoretical Biology & Medical Modelling·Chuan LuoJohn W Clark
Jul 28, 2009·Nonlinear Biomedical Physics·Federico AlettiGiuseppe Baselli
Dec 14, 2011·PloS One·Marsha E BatesIgor Mezić
Nov 19, 2011·Psychophysiology·Evgeny G VaschilloMarsha E Bates
Jul 3, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Nikolai AljuriRichard J Cohen
Mar 31, 2005·Physiological Measurement·Xinshu XiaoRamakrishna Mukkamala

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