PMID: 6989413Apr 1, 1980Paper

Theoretical considerations in the equilibrium binding of myosin fragments on F-actin

Biophysical Chemistry
T L Hill, E Eisenberg

Abstract

In a previous paper, equilibrium ocnstants for the binding of myosin fragments onto F-actin were assumed known and the statistical problems encountered when the actin sites are occupied to an arbitrary fractional extent were analyzed. The object of the present paper is to attempt to understand the observed order of magnitude of these equilibrium constants in terms of the statistical mechanical degrees of freedom involved. That is, we examine here the equilibrium constants themselves rather than the statistical consequences of the equilibrium constants. The treatment given amounts to a semi-quantitative sketch or outline of the problem. Structural details are much too uncertain to warrant a careful and rigorous treatment at this time. But the discussion suffices to establish the essential qualitative features of the problem. The procedure used is to examine the important equilibrium constants, one at a time, in terms of the factors (partition functions) that contribute to each constant, together with numerical estimates for these factors.

References

Dec 28, 1976·Biochemistry·H D White, E W Taylor
Apr 20, 1976·Biochemistry·T L Hill, E Eisenberg
Jan 1, 1978·Progress in Biophysics and Molecular Biology·E Eisenberg, T L Hill
Dec 12, 1978·Biochemistry·S S Margossian, S Lowey
Jan 1, 1979·CRC Critical Reviews in Biochemistry·E W Taylor
Jan 10, 1978·Biochemistry·S Highsmith
Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·L E Greene, E Eisenberg
Jan 26, 1978·Nature·G Offer, A Elliott
Apr 30, 1977·Archives of Biochemistry and Biophysics·S Highsmith
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·T L Hill
Apr 1, 1988·Revue française de transfusion et immuno-hématologie·M J TelenT Young
Mar 1, 1972·Immunochemistry·D M Crothers, H Metzger
Oct 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·T L Hill, G M White
Feb 1, 1980·Biophysical Journal·E EisenbergY Chen

Related Concepts

Isoactin
Mathematics
Actomyosin Adenosinetriphosphatase
Plasma Protein Binding Capacity
Protein Conformation
Thermodynamics
Meromyosin Subfragments

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