PMID: 11604262Oct 18, 2001Paper

Theoretical considerations on the in vivo intestinal permeability determination by means of the single pass and recirculating techniques

International Journal of Pharmaceutics
M Grassi, G Cadelli

Abstract

This paper deals with the development of proper mathematical models for the calculation of the in vivo rat intestinal drug permeability resorting to two different kinds of experimental methods: the single pass and the recirculating perfusion techniques. In particular, in the single pass case, attention is focused on the effect of water exchange between the flowing solution and the intestinal wall, as this can sensibly affect the permeability determination. In both the single pass and the recirculating perfusion method, a complete radial mixing of the flowing solution is supposed to hold, so that drug concentration and solution velocity are radius independent. Nevertheless, they depend on the intestinal axial position. Accordingly, two distinct models are built up by resorting to microscopic mass balances. The reasonably good data fitting performed by the recirculating perfusion model ensures that the most important factors affecting the passive drug (Antipyrine) diffusion through a rat intestinal wall are properly accounted for. Moreover, the reliability of the developed models and the experimental tests is proved by the fact that the drug (Antipyrine) permeability determined by means of the two methods is statistically equal.

Citations

Jul 24, 2012·Biomedical Microdevices·Ju Hun YeonJe-Kyun Park
Apr 28, 2011·Pharmaceutical Research·Natalie L TrevaskisChristopher J H Porter
Jul 9, 2013·Journal of Pharmacological and Toxicological Methods·Zhiqiang LuoLi Wei
Aug 31, 2007·Drug Development and Industrial Pharmacy·Subrata MallickPintu K De
Jan 16, 2013·Drug Development and Industrial Pharmacy·Shan GuanYuan Huang
Feb 6, 2004·Journal of Pharmaceutical Sciences·F MerianiM Grassi
May 20, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alistair TavernerRandall J Mrsny
Jan 1, 2013·Journal of Pharmaceutics·Bharat Bhushan Subudhi, Surjyanarayan Mandal
Nov 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Guo ChenGang Cheng
Feb 11, 2009·Analytical Chemistry·Ju Hun Yeon, Je-Kyun Park

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