Theoretical frameworks and approaches used within the Reserve, Resilience and Protective Factors professional interest area of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment.

Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
David Bartrés-FazPrashanthi Vemuri

Abstract

Reserve, resilience, maintenance, and related concepts are intensely debated in aging and Alzheimer's disease research. Through a short survey, we gathered information about theoretical concepts and methodologies used among research groups of the Reserve, Resilience, and Protective Factors Professional Interest Area of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment. Overall 53 research groups responded. Reserve and resilience were the most frequently used conceptual frameworks. Education, occupation, leisure, and social activities were frequently used as measures, as were longitudinal designs. Neuropsychological assessments were almost universal, and usage of imaging biomarkers was frequent. In observational-epidemiological study designs, resilience and reserve together (vs reserve alone) were commonly used as theoretical frameworks. We provide a first description of concepts and methodologies used among reserve and resilience researchers. This will inform initiatives aiming to reach consensus on terminology and applications to establish common definitions.

References

Apr 12, 2011·Brain : a Journal of Neurology·Prashanthi VemuriUNKNOWN Alzheimer's Disease Neuroimaging Initiative
May 1, 2012·Trends in Cognitive Sciences·Lars NybergLars Bäckman
Mar 15, 2013·Neurology·Michael EwersUNKNOWN Alzheimer's Disease Neuroimaging Initiative (ADNI)
Dec 21, 2013·Acta Neuropathologica·David A BennettJulie A Schneider
Feb 20, 2014·Progress in Neurobiology·Anders M FjellUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Mar 30, 2018·Neurology·Eider M Arenaza-Urquijo, Prashanthi Vemuri
Apr 15, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Clifford R JackUNKNOWN Contributors
Oct 12, 2018·Nature Reviews. Neuroscience·Roberto CabezaM Natasha Rajah
Mar 13, 2019·Alzheimer's Research & Therapy·Thomas J MontineLon R White
Sep 15, 2019·Human Brain Mapping·Avinash ChandraUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Apr 7, 2020·Molecular Psychiatry·Henrik Zetterberg, Barbara B Bendlin
Apr 24, 2020·Nature Reviews. Neurology·Nicholas J AshtonDag Aarsland

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