Theoretical implications of the biomechanical fracture threshold.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Tony M Keaveny, Mary L Bouxsein

Abstract

Because of the dichotomous nature of a bone fracture, when Phi, the ratio of the applied impact force to the bone strength, is greater than a critical value--the biomechanical fracture threshold--fracture should occur. We sought to elucidate the conceptual implications of this biomechanical fracture threshold with application to hip fracture. We used data from the PaTH study, a 2-yr clinical trial in postmenopausal women treated with alendronate, PTH, or their combination. Outcomes included the force applied to the hip in a sideways fall as estimated from subject height and weight; femoral strength as determined by QCT-based finite element analysis; the load-to-strength ratio Phi; and total hip areal BMD from DXA. Results indicated that those with "very low" femoral strength (<2000 N) invariably had load-to-strength ratio Phi values well above the theoretical biomechanical fracture threshold (Phi = 1), but those with "moderately low" femoral strength (2000-4000 N) displayed Phi values both above and below the theoretical biomechanical fracture threshold. This finding implies that the risk of a hip fracture can be high in those with only moderately low BMD because femoral strength can be low relative to fall impact forces. The o...Continue Reading

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