Theoretical investigations of Rh-catalyzed asymmetric 1,4-addition to enones using planar-chiral phosphine-olefin ligands

Journal of Computational Chemistry
Kyohei KawashimaSeiji Mori

Abstract

Recently, planar-chiral phosphine-olefin ligands based on (η6 -arene)chromium(0) and (η5 -cyclopentadienyl)manganese(I), which are known as first- and second-generation, respectively, have been developed. These ligands were employed for Rh-catalyzed asymmetric 1,4-addition to enones. First-generation ligands involve high enantioselectivity for cyclic enones (>98% ee). Second-generation ligands involve high enantioselectivity for not only cyclic enones but also for acyclic enones (>98% ee). In this study, we have performed DFT calculations to investigate the origin of enantioselectivity. The theoretical values of enantioselectivities were found to be in good agreement with the experimental values obtained for a cyclic enone, 2-cyclopenten-1-one, using both the first- and second-generation ligands. Regarding an acyclic enone, 3-penten-2-one, it was found that the s-cis type decreases the enantioselectivity because the transition states in the s-cis type have a large steric repulsion. Energy decomposition analysis (EDA) and natural bond orbital (NBO) analysis indicate that it is important to study the orbital interactions in the transition states of the insertion step for the acyclic enone attacked from si-face with the second-gen...Continue Reading

References

Dec 5, 1998·Journal of Molecular Biology·P Chakrabarti, S Chakrabarti
Aug 14, 2003·Chemical Reviews·Tamio Hayashi, Kaori Yamasaki
Sep 8, 2004·Chemistry : a European Journal·Pascal MaireHansjörg Grützmacher
Oct 8, 2004·Journal of the American Chemical Society·Fernando LópezBen L Feringa
Jun 1, 2005·Chemistry : a European Journal·Shangjie XuHendrik Zipse
Apr 25, 2006·Physical Chemistry Chemical Physics : PCCP·Florian Weigend
Jan 26, 2007·Journal of the American Chemical Society·Wei-Liang DuanTamio Hayashi
Mar 4, 2011·Journal of Computational Chemistry·Stefan GrimmeLars Goerigk
Dec 14, 2011·Chemistry : a European Journal·Silvia GosiewskaJohn M Brown
Mar 14, 2013·Journal of Computational Chemistry·Eric D GlendeningFrank Weinhold
Sep 1, 1996·Accounts of Chemical Research·G R Desiraju

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