Theoretical model and characteristics of mitochondrial thermogenesis

Biophysical Reports
Jian-Sheng Kang

Abstract

Based on the first law of thermodynamics and the thermal diffusion equation, the deduced theoretical model of mitochondrial thermogenesis satisfies the Laplace equation and is a special case of the thermal diffusion equation. The model settles the long-standing question of the ability to increase cellular temperature by endogenous thermogenesis and explains the thermogenic characteristics of brown adipocytes. The model and calculations also suggest that the number of free available protons is the major limiting factor for endogenous thermogenesis and its speed.

References

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Jan 26, 2018·PLoS Biology·Nick Lane
Jan 26, 2018·PLoS Biology·Dominique ChrétienMalgorzata Rak

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Citations

Aug 3, 2019·Communications Biology·Manjunath C RajagopalSanjiv Sinha
Jan 12, 2020·Communications Biology·Manjunath C RajagopalSanjiv Sinha
Nov 29, 2020·Biochimica Et Biophysica Acta. Bioenergetics·David MacherelOlivier Bourgeois

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