Theoretical modeling in hemodynamics of microcirculation

Microcirculation : the Official Journal of the Microcirculatory Society, Inc
Jack Lee, Nicolas P Smith

Abstract

Over the past decades, theoretical modeling has become an indispensable component of research into the hemodynamics of microcirculation. Numerous studies rely on modeling to provide quantitative insights into the interacting biophysical mechanisms that govern microcirculatory flow. The mechanical deformation of hematocytes has been addressed by continuum and molecular-informed computational models based on a growing body of experimental information. Theoretical analyses of single-vessel flow and blood rheology have led to a range of modeling approaches. Until recently, computational constraints limited direct simulations of multi-particle flows involving deformation and/or aggregation, but recent studies have begun to address this challenge. Network-level analyses have provided insights into the biophysical principles underlying the design of the microcirculation. This approach has been used to complement available experimental data and to derive empirical models of microvascular blood rheology. Continued increases in computational performance applied to current modeling techniques will enable larger scale simulations. In order to exploit this opportunity, integration of diverse theoretical approaches within a multi-scale frame...Continue Reading

Citations

May 9, 2012·Annals of Biomedical Engineering·Jack Lee, Nicolas P Smith
May 9, 2012·Annals of Biomedical Engineering·Eugene KimArvind P Pathak
Nov 3, 2010·Journal of Biomechanical Engineering·Andrea BonfiglioJennifer H Siggers
Jun 21, 2014·PloS One·Joseph M SherwoodStavroula Balabani
Apr 18, 2012·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Brendan C FryTimothy W Secomb
Jun 20, 2012·Journal of Biophotonics·Susan M Daly, Martin J Leahy
Feb 20, 2018·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Peter M RasmussenAxel R Pries
May 8, 2018·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Qing PanGangmin Ning
Nov 6, 2013·Journal of Biomechanical Engineering·Qing PanGangmin Ning
Oct 26, 2018·International Journal for Numerical Methods in Biomedical Engineering·Luca PossentiPaolo Zunino
Mar 21, 2019·Mathematical Medicine and Biology : a Journal of the IMA·Rebecca J ShipleyTimothy W Secomb
Mar 6, 2019·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Vibujithan VigneshwaranNicolas P Smith
Apr 7, 2010·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Ken-ichi Tsubota, Shigeo Wada
Dec 24, 2013·American Journal of Physiology. Heart and Circulatory Physiology·P van HorssenM Siebes
Jun 19, 2018·Biomechanics and Modeling in Mechanobiology·Benjamin OwenAlistair Revell
Feb 17, 2017·Journal of the Royal Society, Interface·B Zeller-PlumhoffP Schneider

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