Theoretical Modeling of Cognitive Dysfunction in Schizophrenia by Means of Errors and Corresponding Brain Networks

Frontiers in Psychology
Yuliya ZaytsevaFilip Španiel

Abstract

The current evidence of cognitive disturbances and brain alterations in schizophrenia does not provide the plausible explanation of the underlying mechanisms. Neuropsychological studies outlined the cognitive profile of patients with schizophrenia, that embodied the substantial disturbances in perceptual and motor processes, spatial functions, verbal and non-verbal memory, processing speed and executive functioning. Standardized scoring in the majority of the neurocognitive tests renders the index scores or the achievement indicating the severity of the cognitive impairment rather than the actual performance by means of errors. At the same time, the quantitative evaluation may lead to the situation when two patients with the same index score of the particular cognitive test, demonstrate qualitatively different performances. This may support the view why test paradigms that habitually incorporate different cognitive variables associate weakly, reflecting an ambiguity in the interpretation of noted cognitive constructs. With minor exceptions, cognitive functions are not attributed to the localized activity but eventuate from the coordinated activity in the generally dispersed brain networks. Functional neuroimaging has progressiv...Continue Reading

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Citations

Oct 28, 2019·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Amirhossein JafarianKarl Friston
Apr 4, 2021·Brain Sciences·Gabriel G De la TorreSara González-Torre
Jul 16, 2021·Behavioural Brain Research·Kristýna MalenínskáTereza Nekovářová

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