PMID: 8609450Feb 1, 1996Paper

Theoretical predictions on the equality of radiation-produced dicentrics and translocations detected by chromosome painting

International Journal of Radiation Biology
J N LucasR K Sachs

Abstract

Existing models of chromosome aberrations produced by ionizing-radiation predict equal numbers of dicentrics and translocations if the dose is so low that complex aberrations can be ignored. We show that, for a specific subset of aberrations detected by FISH, dicentric/translocation equality is predicted even at higher doses. Assuming one-colour whole-chromosome painting (with unpainted chromosomes counterstained and centromeres recognizable) the relevant restriction is that the final metaphase pattern be, in the terminology of Simpson and Savage, 'apparently simple'. This means that the painted pattern is required to have the colour/centromere appearance corresponding to a single complete reciprocal exchange but its actual formation, as reflected for example in lengths, is allowed to be more complicated. The restriction to apparent simplicity is significantly less limiting than ignoring all complex aberrations. Our analysis of predicted dicentric/translocation equality in this case uses examples, a combinatorial counting method, Monte Carlo computer programs, and a duality proof. However, we argue that for 'visibly complex' dicentrics or translocations, no similar equality is expected in general. Corresponding experimental res...Continue Reading

References

Jul 1, 1992·International Journal of Radiation Biology·J N LucasJ Gray
Oct 1, 1992·International Journal of Radiation Biology·R K SachsW F Morgan
Jan 1, 1995·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·P J Simpson, J R Savage
Jan 1, 1995·Cytogenetics and Cell Genetics·J D TuckerC Shasserre
Jan 1, 1995·International Journal of Radiation Biology·P J Simpson, J R Savage
Mar 1, 1995·International Journal of Radiation Biology·J L FernándezA A Edwards
Nov 1, 1994·International Journal of Radiation Biology·A T NatarajanS Vermeulen
Aug 1, 1993·International Journal of Radiation Biology·T Straume, J N Lucas
Feb 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J N Lucas, R K Sachs

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Citations

Jan 1, 1997·International Journal of Radiation Biology·R K SachsD J Brenner
Jan 1, 1997·International Journal of Radiation Biology·J N LucasC E Burk
Sep 1, 1996·International Journal of Radiation Biology·J N LucasT Straume
Apr 17, 2001·Radiation Research·B D Loucas, M N Cornforth
Oct 19, 2002·Radiation Research·Rainer K SachsPhilip Hahnfeldt
Aug 17, 2004·Radiation and Environmental Biophysics·Francesca Ballarini, Andrea Ottolenghi
Jan 8, 2016·Dose-response : a Publication of International Hormesis Society·B A UlshD R Boreham
Sep 28, 2004·Radiation Research·Bradford D LoucasMichael N Cornforth

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