Theoretical studies on the regulation of anaerobic glycolysis and its influence on oxidative phosphorylation in skeletal muscle

Biophysical Chemistry
Bernard Korzeniewski, Piotr Liguzinski

Abstract

It is shown, using the computer model of glycolysis in skeletal muscle developed recently by Lambeth and Kushmerick (Ann. Biomed. Bioenerg, 30 (2001) 19-34) incorporated into the computer model of oxidative phosphorylation developed by Korzeniewski et al. (Biophys. Chem. 83 (2001) 19-34) that the regulation of glycolysis by ADP, AMP and P(i) is decidedly insufficient to explain the large increase in the glycolytic flux during transition from rest to intensive exercise in intact skeletal muscle. Computer simulations based on a simple kinetic description of the glycolytic ATP and H(+) production strongly suggests that glycolysis must be directly activated during muscle contraction. They also demonstrate that the inhibition of glycolysis by H(+) is needed to explain the transient activation of this pathway at the onset of exercise as well as the duration time and extent of the initial alkalization after the onset of exercise. Finally, it is shown that ATP supply from anaerobic glycolysis slows down the VO(2) kinetics during rest-to-work transition.

References

Jan 1, 1994·Medicine and Science in Sports and Exercise·R A Meyer, J M Foley
Aug 7, 1996·Biochimica Et Biophysica Acta·D F Rolfe, M D Brand
May 23, 1998·The Biochemical Journal·B Korzeniewski
Mar 10, 2001·Biochimica Et Biophysica Acta·B Korzeniewski
Jul 28, 2001·Exercise and Sport Sciences Reviews·R L HughsonM E Houston
Jul 23, 2002·The Biochemical Journal·Bernard Korzeniewski, Jerzy A Zoladz

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Citations

Nov 18, 2006·Annals of Biomedical Engineering·Jaeyeon KimMarco E Cabrera
Dec 17, 2009·Annals of Biomedical Engineering·Karlien K CeelenC W J Oomens
Oct 3, 2008·American Journal of Physiology. Cell Physiology·Yanjun LiMarco E Cabrera
Nov 6, 2008·Expert Opinion on Drug Safety·Kalyanasundaram SubramanianSrivatsan Raghunathan
Jun 15, 2007·Biophysical Chemistry·Bernard Korzeniewski
Jun 14, 2005·Biophysical Chemistry·Bernard Korzeniewski, Jerzy A Zoladz
Apr 23, 2015·Biophysical Chemistry·Nicor Lengert, Barbara Drossel
May 8, 2014·Journal of Theoretical Biology·Atefeh GhorbaniaghdamMario Jolicoeur
Aug 30, 2018·Physiological Reports·Bernard KorzeniewskiJerzy A Zoladz
Sep 4, 2012·Cellular and Molecular Bioengineering·Yanjun LiGerald M Saidel
Mar 14, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Piotr Liguzinski, Bernard Korzeniewski
Aug 29, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jerzy A ZoladzBernard Korzeniewski
Nov 30, 2005·The Journal of Biological Chemistry·Bernard Korzeniewski
Jun 5, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gwenael LayecRussell S Richardson
Mar 15, 2015·Journal of Applied Physiology·Bernard Korzeniewski, Jerzy A Zoladz
Jun 20, 2006·The Journal of Physiological Sciences : JPS·Bernard Korzeniewski, Jerzy A Zoladz
Jun 9, 2006·American Journal of Physiology. Cell Physiology·Piotr Liguzinski, Bernard Korzeniewski
Jun 22, 2013·Journal of Applied Physiology·Bernard Korzeniewski, Jerzy A Zoladz
Aug 11, 2019·European Journal of Applied Physiology·Bernard Korzeniewski
Nov 20, 2020·Journal of Applied Physiology·Bernard Korzeniewski, Harry B Rossiter

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