Theoretical study on the polymer translocation into an attractive sphere

The Journal of Chemical Physics
Li-Zhen SunHaibin Li

Abstract

We report a non-sampling model, combining the blob method with the standard lattice-based approximation, to calculate the free energy for the polymer translocation into an attractive sphere (i.e., spherical confined trans side) through a small pore. The translocation time is then calculated by the Fokker-Planck equation based on the free energy profile. There is a competition between the confinement effect of the sphere and the polymer-sphere attraction. The translocation time is increased due to the confinement effect of the sphere, whereas it is reduced by the polymer-sphere attraction. The two effects offset each other at a special polymer-sphere attraction which is dependent on the sphere size, the polymer length, and the driving force. Moreover, the entire translocation process can be divided into an uncrowded stage where the polymer does not experience the confinement effect of the sphere and a crowded stage where the polymer is confined by the sphere. At the critical sphere radius, the durations of the two (uncrowded and crowded) stages are the same. The critical sphere radius R* has a scaling relation with the polymer length N as R* ∼ Nβ. The calculation results show that the current model can effectively treat the tran...Continue Reading

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Citations

Jan 17, 2019·The Journal of Chemical Physics·Li-Zhen SunHaibin Li
Apr 29, 2021·Soft Matter·Jia ChenMeng-Bo Luo
Jul 21, 2021·Scientific Reports·Pai-Yi Hsiao, Wei-Yei Chen

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