Theory of Epithelial Cell Shape Transitions Induced by Mechanoactive Chemical Gradients

Biophysical Journal
K DasbiswasNir S Gov

Abstract

Cell shape is determined by a balance of intrinsic properties of the cell as well as its mechanochemical environment. Inhomogeneous shape changes underlie many morphogenetic events and involve spatial gradients in active cellular forces induced by complex chemical signaling. Here, we introduce a mechanochemical model based on the notion that cell shape changes may be induced by external diffusible biomolecules that influence cellular contractility (or equivalently, adhesions) in a concentration-dependent manner-and whose spatial profile in turn is affected by cell shape. We map out theoretically the possible interplay between chemical concentration and cellular structure. Besides providing a direct route to spatial gradients in cell shape profiles in tissues, we show that the dependence on cell shape helps create robust mechanochemical gradients.

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Citations

Apr 3, 2019·Physical Review. E·Pierre A Haas, Raymond E Goldstein
Jun 6, 2018·The Journal of Chemical Physics·Saroj Kumar Nandi, Sam A Safran
Dec 29, 2020·Proceedings. Mathematical, Physical, and Engineering Sciences·Tamara A TambyahMatthew J Simpson
Jan 24, 2021·Nature Reviews. Molecular Cell Biology·Claudio Collinet, Thomas Lecuit
May 13, 2021·Soft Matter·Andrei Zakharov, Kinjal Dasbiswas
Jun 24, 2021·The European Physical Journal. E, Soft Matter·Andrei Zakharov, Kinjal Dasbiswas
Sep 25, 2018·Bio Systems·Daria M KupaevaStanislav V Kremnyov
Nov 17, 2021·Soft Matter·Saraswat Bhattacharyya, Julia M Yeomans
Dec 7, 2021·PLoS Computational Biology·Fu-Lai WenTatsuo Shibata

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