Theory of Mind in Patients with Epilepsy: a Systematic Review and Meta-analysis

Neuropsychology Review
Elizabeth StewartS Lah

Abstract

The ability to understand our own thoughts, intentions, beliefs and emotions and those of others (Theory of Mind; ToM) is a high-order social cognitive skill that is vital for social interaction and which has been found to be impaired in patients with epilepsy. Studies examining ToM in patients with epilepsy, however, have yielded inconsistent findings. The main aim of this study is to determine whether the magnitude of ToM deficits varies as a function of the site of epilepsy focus and/or the type of ToM task used. Electronic databases searches included Psychinfo, Medline/PubMed and EMBASE. Studies were included if they examined a group of patients with epilepsy and a group of healthy controls, reported original research, were published in the English language in peer reviewed journals, and used one of five empirically validated measures of ToM: False Belief, Reading the Mind in the Eyes Task (RMET), Faux-pas, Strange Stories, Cartoon ToM vignettes. Twelve studies were identified, ten included adults and two included children with epilepsy. Findings revealed marked ToM deficits in adults with focal seizures emanating from core brain regions underpinning ToM: temporal and frontal lobes (frontal lobe epilepsy, FLE; temporal lobe...Continue Reading

References

Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Nov 18, 1997·Journal of Child Psychology and Psychiatry, and Allied Disciplines·S Baron-CohenM Robertson
Aug 26, 1999·Trends in Cognitive Sciences·J Perner, B Lang
Nov 27, 1999·Science·C D Frith, U Frith
Dec 10, 1999·Journal of Autism and Developmental Disorders·S Baron-CohenK Plaisted
Mar 31, 2001·Journal of Child Psychology and Psychiatry, and Allied Disciplines·S Baron-CohenI Plumb
Jun 19, 2001·Child Development·H M WellmanJ Watson
Aug 2, 2001·Child Development·S M Carlson, L J Moses
Aug 8, 2002·Journal of the International Neuropsychological Society : JINS·Kathleen Culhane-ShelburneDaniel Glaze
Dec 3, 2002·Neuropsychologia·Valerie E StoneAndrew Young
Feb 11, 2003·Epilepsy Research·Melinda A NolanAnn M E Bye
Feb 14, 2003·Trends in Cognitive Sciences·Helen L. Gallagher, Christopher D. Frith
Mar 5, 2004·Brain : a Journal of Neurology·Chris M BirdMasud Husain
Mar 27, 2004·Current Treatment Options in Neurology·Joseph E. Sullivan, Dennis J. Dlugos
May 25, 2004·Brain : a Journal of Neurology·P ShawA S David
Feb 16, 2005·Epilepsy & Behavior : E&B·Rochelle CaplanRaman Sankar
Mar 29, 2005·European Child & Adolescent Psychiatry·Nils KalandDorte Gottlieb
Apr 12, 2005·Science·Kristine H Onishi, Renée Baillargeon
Jun 7, 2005·Neuropsychologia·Rebecca Saxe, Anna Wexler
Sep 17, 2005·Epilepsy & Behavior : E&B·Annette FarrantMichael Koutroumanidis
Oct 29, 2005·Epilepsy & Behavior : E&B·Heidi E Kirsch
Mar 23, 2006·Nature Reviews. Neuroscience·David M Amodio, Chris D Frith
Jan 5, 2007·Epilepsia·Martina SchacherHennric Jokeit
Jan 27, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Chris D Frith
Mar 30, 2007·Brain : a Journal of Neurology·Ingrid R OlsonYoussef Ezzyat
Mar 6, 2009·Epilepsy Research·Anna R GiovagnoliSilvana Franceschetti
Jun 11, 2009·Journal of Clinical Neurology·Sung-Pa Park, Soon-Hak Kwon
Jul 23, 2009·Annals of Internal Medicine·David MoherUNKNOWN PRISMA Group
Aug 28, 2009·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Elke KalbeJosef Kessler
Feb 9, 2010·Developmental Science·Iroise DumontheilSarah-Jayne Blakemore

❮ Previous
Next ❯

Citations

Oct 8, 2016·Neurobiology of Aging·Maryam ZiaeiJulie D Henry
Oct 21, 2016·Seizure : the Journal of the British Epilepsy Association·Bettina K Steiger, Hennric Jokeit
Jan 10, 2018·Frontiers in Neurology·Noemi FaeddaVincenzo Guidetti
Feb 6, 2020·Frontiers in Psychology·Cindy BeaudoinMiriam H Beauchamp
Dec 19, 2018·Proceedings of the National Academy of Sciences of the United States of America·Dinesh UpadhyaAshok K Shetty
Jul 10, 2019·Epilepsy & Behavior : E&B·Boulenouar MesraouaAli A Asadi-Pooya
Mar 18, 2021·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Lydia van den BergJaap J van der Meere
Apr 15, 2021·Psychiatry Investigation·Se Jun KooSuk Kyoon An
Apr 27, 2020·Seizure : the Journal of the British Epilepsy Association·Ellen Marise LimaKette D R Valente
Nov 28, 2017·Neuroscience and Biobehavioral Reviews·Jack CotterJennifer H Barnett

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.