Theory of mind network activity is altered in subjects with familial liability for schizophrenia

Social Cognitive and Affective Neuroscience
Sebastian MohnkeH Walter

Abstract

As evidenced by a multitude of studies, abnormalities in Theory of Mind (ToM) and its neural processing might constitute an intermediate phenotype of schizophrenia. If so, neural alterations during ToM should be observable in unaffected relatives of patients as well, since they share a considerable amount of genetic risk. While behaviorally, impaired ToM function is confirmed meta-analytically in relatives, evidence on aberrant function of the neural ToM network is sparse and inconclusive. The present study therefore aimed to further explore the neural correlates of ToM in relatives of schizophrenia. About 297 controls and 63 unaffected first-degree relatives of patients with schizophrenia performed a ToM task during functional magnetic resonance imaging. Consistent with the literature relatives exhibited decreased activity of the medial prefrontal cortex. Additionally, increased recruitment of the right middle temporal gyrus and posterior cingulate cortex was found, which was related to subclinical paranoid symptoms in relatives. These results further support decreased medial prefrontal activation during ToM as an intermediate phenotype of genetic risk for schizophrenia. Enhanced recruitment of posterior ToM areas in relatives...Continue Reading

References

Apr 2, 2003·The American Journal of Psychiatry·Irving I Gottesman, Todd D Gould
Apr 2, 2003·The American Journal of Psychiatry·Joseph H CallicottDaniel R Weinberger
Jun 26, 2003·Acta Psychiatrica Scandinavica·I JanssenJim van Os
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH
Jan 27, 2004·NeuroImage·Joseph A MaldjianJonathan H Burdette
Jun 21, 2005·NeuroImage·H E M den OudenS-J Blakemore
May 2, 2006·Journal of Magnetic Resonance Imaging : JMRI·Lee Friedman, Gary H Glover
Aug 15, 2006·Psychiatry Research·Dominic MarjoramStephen Lawrie
Sep 22, 2006·Nature Reviews. Neuroscience·Andreas Meyer-Lindenberg, Daniel R Weinberger
Oct 3, 2006·The British Journal of Psychiatry : the Journal of Mental Science·Stephen J GlattMing T Tsuang
Jul 3, 2007·The British Journal of Psychiatry : the Journal of Mental Science·Mirjam SprongHerman van Engeland
Oct 16, 2007·Schizophrenia Research·Dagmar VersmissenLydia Krabbendam
Mar 18, 2008·NeuroImage·Liane Young, Rebecca Saxe
Apr 3, 2008·Human Brain Mapping·Frank Van Overwalle
Jul 9, 2008·Psychological Bulletin·Sarah I Tarbox, Michael F Pogue-Geile
Aug 5, 2008·Nature Genetics·Michael C O'DonovanUNKNOWN Molecular Genetics of Schizophrenia Collaboration
Nov 27, 2008·Human Brain Mapping·Sarah J Carrington, Anthony J Bailey
Mar 17, 2009·Social Cognitive and Affective Neuroscience·Henrik WalterBruno G Bara
Jul 21, 2009·Human Brain Mapping·Jonathan B FreemanNalini Ambady
Oct 13, 2009·Schizophrenia Research·S AnselmettiR Cavallaro
Nov 26, 2009·Proceedings of the National Academy of Sciences of the United States of America·Sarina M RodriguesDacher Keltner
Jul 14, 2010·Neuroscience and Biobehavioral Reviews·Anne-Kathrin J FettLydia Krabbendam
Aug 23, 2011·Clinical Psychology Review·Sarah I Tarbox, Michael F Pogue-Geile
Sep 6, 2011·European Archives of Psychiatry and Clinical Neuroscience·Christiane MontagJürgen Gallinat
Sep 29, 2011·Schizophrenia Research·Pritha DasGin S Malhi
Jan 1, 1992·Journal of Psychopharmacology·C D Frith
Feb 24, 2012·Developmental Science·Christine LacknerJeanette J A Holden
Mar 13, 2012·Schizophrenia Research·Arija MaatUNKNOWN GROUP Investigators

❮ Previous
Next ❯

Citations

Dec 5, 2015·Frontiers in Psychology·Lucy K BicksHirofumi Morishita
Oct 30, 2016·Neuropsychologia·Andrew K MartinBryan Mowry
Jan 15, 2018·Psychopharmacology·Young-A LeeYukiori Goto
Feb 15, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Zhimin YanDaniela Mier
Mar 10, 2021·Social Cognitive and Affective Neuroscience·David Dodell-FederChristine I Hooker
Nov 7, 2019·Journal of Psychiatric Research·Ksenija VucurovicArthur Kaladjian

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.