Theory of robustness of irreversible differentiation in a stem cell system: chaos hypothesis

Journal of Theoretical Biology
C Furusawa, K Kaneko

Abstract

Based on an extensive study of a dynamical systems model of the development of a cell society, a novel theory for stem cell differentiation and its regulation is proposed as the "chaos hypothesis". Two fundamental features of stem cell systems-stochastic differentiation of stem cells and the robustness of a system due to regulation of this differentiation-are found to be general properties of a system of interacting cells exhibiting chaotic intra-cellular reaction dynamics and cell division, whose presence does not depend on the detail of the model. It is found that stem cells differentiate into other cell types stochastically due to a dynamical instability caused by cell-cell interactions, in a manner described by the Isologous Diversification theory. This developmental process is shown to be stable not only with respect to molecular fluctuations but also with respect to the removal of cells. With this developmental process, the irreversible loss of multipotency accompanying the change from a stem cell to a differentiated cell is shown to be characterized by a decrease in the chemical diversity in the cell and of the complexity of the cellular dynamics. The relationship between the division speed and the loss of multipotency i...Continue Reading

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Citations

Apr 23, 2008·Theory in Biosciences = Theorie in Den Biowissenschaften·Kunihiko Kaneko, Chikara Furusawa
Nov 13, 2008·Cytotechnology·Sowmya Viswanathan, Peter W Zandstra
May 3, 2007·Proceedings. Biological Sciences·Rolf LohausRicardo B R Azevedo
Aug 18, 2009·Genes & Development·Taeko KobayashiRyoichiro Kageyama
Oct 16, 2012·Science·Chikara Furusawa, Kunihiko Kaneko
Oct 25, 2013·Theoretical Biology & Medical Modelling·Tuan D Pham, Kazuhisa Ichikawa
May 19, 2009·Biology Direct·Chikara Furusawa, Kunihiko Kaneko
Apr 19, 2012·PLoS Computational Biology·João F Matias RodriguesHomayoun C Bagheri
Sep 5, 2008·PloS One·Ben D MacArthurRichard O C Oreffo
Jun 7, 2011·Seminars in Cancer Biology·Sui Huang
Nov 26, 2009·Journal of Theoretical Biology·A KoseskaJ García-Ojalvo
Jun 11, 2008·Journal of Theoretical Biology·Akihiko Nakajima, Kunihiko Kaneko
Dec 14, 2007·Journal of Theoretical Biology·K Qu, P Ortoleva
May 4, 2007·Journal of Theoretical Biology·Emmanuel Tannenbaum
Jul 21, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Hiroshi Yoshida, Kunihiko Kaneko
Feb 14, 2008·International Journal of Urology : Official Journal of the Japanese Urological Association·Takehiko Ogawa
Jun 17, 2008·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Kunihiko KanekoMakoto Asashima
Mar 8, 2005·Journal of Theoretical Biology·Hiroshi YoshidaKunihiko Kaneko
Aug 11, 2006·Current Opinion in Biotechnology·Daniel C Kirouac, Peter W Zandstra
Aug 16, 2005·Journal of Theoretical Biology·Shuji Ishihara, Kunihiko Kaneko
Aug 31, 2016·Communicative & Integrative Biology·Kelly G SullivanMichael Levin
Oct 18, 2016·PLoS Computational Biology·Jumpei F YamagishiKunihiko Kaneko
Aug 30, 2003·Chaos·Kunihiko Kaneko, Ichiro Tsuda
Oct 17, 2002·The Anatomical Record·Chikara Furusawa, Kunihiko Kaneko
Sep 21, 2004·Oncogene·Trang Hoang
Mar 16, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Yoshinori Watanabe, Kunihiko Kaneko
Mar 21, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Emmanuel Tannenbaum
Oct 16, 2013·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Yusuke Goto, Kunihiko Kaneko
Jul 17, 2004·Current Opinion in Hematology·Markus Loeffler, Ingo Roeder
Feb 9, 2017·Proceedings of the National Academy of Sciences of the United States of America·Tomoaki MatsuuraYoshihiro Shimizu
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Oct 18, 2020·BMC Bioinformatics·Eugenio AzpeitiaAndreas Wagner
Jan 14, 2021·IScience·Hiroto Q YamaguchiHiroki R Ueda

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