Theranostic approaches in nuclear medicine: current status and future prospects

Expert Review of Medical Devices
Luca FilippiOreste Bagni

Abstract

Introduction: Theranostics is an emerging field in which diagnosis and specific targeted therapy are combined to achieve a personalized treatment approach to the patient. In nuclear medicine clinical practice, theranostics is often performed utilizing the same molecule labeled with two different radionuclides, one radionuclide for imaging and another for therapy.Areas covered: The authors review the clinical applications of different radiopharmaceuticals in the field of interest, including the well-established use of radioactive iodine in differentiated thyroid cancer, radiolabeled metaiodobenzylguanidine (MIBG) in neuroblastoma and the clinical impact of peptide radionuclide receptorial therapy (PRRT) in the management of neuroendocrine tumors. Furthermore, the more cutting-edge and recently introduced theranostic approaches will be reviewed, such as the radioligand therapy with 177Lu-prostate specific membrane antigen (PSMA) and targeted alpha therapy in castration-resistant prostate cancer. Finally, the main applications of PET for the imaging of biomarkers suitable for the non-radionuclide targeted therapy will be covered.Expert opinion: Theranostics is envisaging a revolutionary clinical approach which is deeply connected ...Continue Reading

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Citations

Jul 10, 2020·Cancer Biotherapy & Radiopharmaceuticals·Luca FilippiOrazio Schillaci
Jul 17, 2020·Expert Review of Medical Devices·Luca FilippiClara Nervi
Feb 21, 2021·World Neurosurgery·Juan Armando Mejía-CordovezJosé de La Hoz-Valle
May 1, 2021·International Journal of Molecular Sciences·Chih-Hsien ChangGann Ting
May 1, 2021·International Journal of Molecular Sciences·Nasim VahidfarElisabeth Eppard
Jun 1, 2021·PET Clinics·Margarida Simao RafaelDaniel A Morgenstern
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Natan J W StraathofAndreas I Jensen
Jul 22, 2021·ChemMedChem·Xi Khai Wong, Keng Yoon Yeong
Sep 4, 2021·International Journal of Nanomedicine·Sandra Díez-VillaresMaría de la Fuente
Oct 6, 2021·Expert Review of Medical Devices·Luca Filippi, Orazio Schillaci
Oct 12, 2021·Journal of the Egyptian National Cancer Institute·Luca FilippiOreste Bagni

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