Theranostic Attributes of Acoustic Cluster Therapy and Its Use for Enhancing the Effectiveness of Liposomal Doxorubicin Treatment of Human Triple Negative Breast Cancer in Mice

Frontiers in Pharmacology
Nigel L BushJeffrey Bamber

Abstract

Acoustic cluster therapy (ACT) comprises co-administration of a formulation containing microbubble/microdroplet clusters (PS101), together with a regular medicinal drug (e.g., a chemotherapeutic) and local ultrasound (US) insonation of the targeted pathological tissue (e.g., the tumor). PS101 is confined to the vascular compartment and, when the clusters are exposed to regular diagnostic imaging US fields, the microdroplets undergo a phase-shift to produce bubbles with a median diameter of 22 µm when unconstrained by the capillary wall. In vivo these bubbles transiently lodge in the tumor's microvasculature. Low frequency ultrasound (300 kHz) at a low mechanical index (MI = 0.15) is then applied to drive oscillations of the deposited ACT bubbles to induce a range of biomechanical effects that locally enhance extravasation, distribution, and uptake of the co-administered drug, significantly increasing its therapeutic efficacy. In this study we investigated the therapeutic efficacy of ACT with liposomal doxorubicin for the treatment of triple negative breast cancer using orthotopic human tumor xenografts (MDA-MB-231-H.luc) in athymic mice (ICR-NCr-Foxn1nu). Doxil® (6 mg/kg, i.v.) was administered at days 0 and 21, each time immed...Continue Reading

References

Mar 4, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·H MaedaK Hori
Mar 5, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M E R O'BrienUNKNOWN CAELYX Breast Cancer Study Group
Nov 18, 2004·Cardiovascular Ultrasound·Jeane M TsutsuiRichard Thomas Porter
Mar 25, 2008·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Douglas L MillerJunru Wu
Jan 27, 2009·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Thomas R NelsonCharles C Church
May 27, 2010·British Journal of Cancer·P WorkmanUNKNOWN Committee of the National Cancer Research Institute
Nov 12, 2010·The New England Journal of Medicine·William D FoulkesJorge S Reis-Filho
Mar 19, 2013·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·K Heath Martin, Paul A Dayton
Nov 26, 2013·Advanced Drug Delivery Reviews·I LentackerC T W Moonen
Mar 29, 2014·Advanced Drug Delivery Reviews·Klazina KooimanNico de Jong
Apr 1, 2014·Advanced Drug Delivery Reviews·Johan Unga, Mitsuru Hashida
Sep 27, 2015·International Journal of Pharmaceutics·Per SontumJonny Østensen
Jan 18, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Annemieke van WamelCatharina de Lange Davies
Feb 3, 2016·Ultrasound in Medicine & Biology·Andrew John HealeyJonny Østensen
Feb 21, 2016·Ultrasound in Medicine & Biology·Norio MasumotoMorihito Okada
Oct 19, 2016·Nature Reviews. Clinical Oncology·Giampaolo BianchiniLuca Gianni
Jun 15, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Annemieke van WamelCatharina de Lange Davies
Jun 17, 2016·Science Translational Medicine·Alexandre CarpentierAhmed Idbaih
Jul 31, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kinam Park
Nov 5, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Georg DimcevskiOdd Helge Gilja
Nov 23, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Spiros KotopoulisEmmet McCormack
Apr 27, 2017·Oncotarget·Adriana-Andreea JitariuMarius Raica
Apr 3, 2018·Trends in Cancer·Sara NizzeroMauro Ferrari
Aug 8, 2018·Clinical Medicine Insights. Oncology·Homero GonçalvesMaria Teresa Bustamante Teixeira
Dec 6, 2018·Journal of Medical Imaging and Radiation Sciences·William T TranGregory J Czarnota

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Citations

Jun 27, 2020·Advanced Drug Delivery Reviews·Tao SunSamir Mitragotri
Jul 19, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Marieke OlsmanCatharina de Lange Davies
Aug 31, 2021·ACS Biomaterials Science & Engineering·Kahkashan BansalHimanshu Shekhar

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