Theranostic metal-organic framework core-shell composites for magnetic resonance imaging and drug delivery

Chemical Science
Huai-Xin ZhaoYan-Yan Fu

Abstract

Metal-organic frameworks (MOFs) have shown great potential in designing theranostic probes for cancer diagnosis and therapy due to their unique properties, including versatile structures and composition, tunable particle and pore size, enormous porosity, high surface area, and intrinsic biodegradability. In this study, we demonstrate novel MOF-based theranostic Fe3O4@UiO-66 core-shell composites constructed by in situ growth of a UiO-66 MOF shell on a Fe3O4 core for simultaneous drug delivery and magnetic resonance (MR) imaging. In the composites, the UiO-66 shell is devoted for encapsulating the drug, whereas the Fe3O4 core serves as a MR contrast agent. The Fe3O4@UiO-66 core-shell composites show good biocompatibility, high drug loading capacity, sustained drug release, and outstanding MR imaging capability, as well as effective chemotherapeutic efficacy, demonstrating the feasibility of designing theranostic Fe3O4@UiO-66 core-shell composites for cancer diagnosis and therapy.

References

Jul 13, 2006·Journal of the American Chemical Society·William J RieterWenbin Lin
Aug 10, 2006·Angewandte Chemie·Patricia HorcajadaGérard Férey
Jan 24, 2007·AJR. American Journal of Roentgenology·Dale R BroomeGerald A Kirk
Sep 27, 2008·Journal of the American Chemical Society·Jasmina Hafizovic CavkaKarl Petter Lillerud
Oct 11, 2008·Journal of the American Chemical Society·Kathryn M L TaylorWenbin Lin
Oct 8, 2009·Journal of the American Chemical Society·Kathryn M L Taylor-PashowWenbin Lin
Jul 24, 2010·Angewandte Chemie·Alistair C McKinlayChristian Serre
Nov 26, 2010·Chemical Society Reviews·Arnau CarnéDaniel Maspoch
Dec 4, 2010·Accounts of Chemical Research·Dan ZhaoHong-Cai Zhou
Jun 9, 2011·Accounts of Chemical Research·Joseph Della RoccaWenbin Lin
Nov 19, 2011·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Fangjie XuHongchen Gu
Dec 16, 2011·Chemical Reviews·Patricia HorcajadaChristian Serre
May 22, 2013·Journal of the American Chemical Society·Qiwei TianXiaogang Liu
Aug 16, 2013·Journal of the American Chemical Society·Cheng WangWenbin Lin
Nov 21, 2013·Inorganic Chemistry·Demin LiuWenbin Lin
Jun 13, 2014·Journal of Medicinal Chemistry·Quan HuYu Yang
Jun 25, 2014·The Journal of Physical Chemistry. B·Resmi AnandSandra Monti
Jun 27, 2014·Chemical Communications : Chem Comm·Xiangyang ZhuJianlin Shi
Jul 22, 2014·Chemistry : a European Journal·Tanay KunduRahul Banerjee
Feb 3, 2015·Journal of the American Chemical Society·Ping GuoAdam J Matzger
Jan 13, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Angshuman Ray ChowdhuriSumanta Kumar Sahu
Jan 21, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Cristina Tamames-TabarPatricia Horcajada
Apr 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jianhua ShenChunzhong Li
Oct 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·L Naszályi NagyÉ Kiss

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Citations

Mar 21, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Li-Juan HanHe-Gen Zheng
Feb 16, 2018·Current Medicinal Chemistry·Zhidong LuoJianqiang Liu
Apr 25, 2020·Biotechnology Journal·Johannes W M Osterrieth, David Fairen-Jimenez
Mar 7, 2018·Advanced Healthcare Materials·Jingrong ZhouXiu-Wu Bian
Jul 28, 2019·Chemistry : a European Journal·Brandon HeMatthew R Hill
Nov 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yongmei YangManzhou Zhu
Feb 21, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Liangcan HeYaling Liu
Jul 7, 2017·Chemistry : a European Journal·Ke JiangGuodong Qian
May 19, 2017·Advanced Materials·Ronald McNeil, Paul J Paukstelis
Jun 2, 2020·Biotechnology Journal·Jorge Parra-NietoAlejandro Baeza
Apr 4, 2017·Advanced Materials·Ming-Xue Wu, Ying-Wei Yang
Mar 28, 2017·Chemical Society Reviews·N Scott BobbittRandall Q Snurr
Apr 27, 2019·The Journal of Pharmacy and Pharmacology·Yicong ZhangHang T Ta
Jun 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yongmei YangManzhou Zhu
Nov 3, 2020·Chemical Society Reviews·Ricardo F MendesFilipe A Almeida Paz
Dec 8, 2020·Chemical Society Reviews·Jintong LiuJianping Lei
Jan 12, 2021·Biomaterials Science·Monireh FalsafiMona Alibolandi
Feb 2, 2021·Chemical Society Reviews·Jiong ZhouFeihe Huang
Feb 14, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Saeid KargozarFrancesco Baino
Feb 24, 2021·ACS Applied Materials & Interfaces·Navid RabieeMohammadreza Shokouhimehr
Dec 24, 2019·Seminars in Cancer Biology·Mohammed Razeeth Shait MohammedMohammad Imran Khan
Apr 29, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Alireza HashemzadehMasoud Mirzaei
Apr 29, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Fatma Demir Duman, Ross S Forgan

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Methods Mentioned

BETA
transmission electron microscopy
X-ray

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