Theranostic MRI liposomes for magnetic targeting and ultrasound triggered release of the antivascular CA4P.

Journal of Controlled Release : Official Journal of the Controlled Release Society
Caroline J ThébaultBich-Thuy Doan

Abstract

Theranostic nanocarriers of antivascular drug encapsulated in thermosensitive ultramagnetic liposomes can be advantageously designed to provide a locally high concentration and an active delivery, with image-guided Magnetic Resonance Imaging (MRI) so as to reliably cure tumor. We propose a novel therapeutic strategy consisting of the magnetic accumulation of Ultra Magnetic Liposomes (UML) followed by High-Intensity Focused Ultrasound (HIFU) to trigger the release of an antivascular agent monitored by MRI. For this purpose, we co-encapsulated Combretastatin A4 phosphate (CA4P), a vascular disrupting agent, in the core of UML to obtain CA4P-loaded thermosensitive Ultra Magnetic Liposomes (CA4P-UML). To assess the HIFU parameters, the CA4P release has been triggered in vitro by local heating HIFU at the lipids transition temperature. Morphology of endothelial cells was assessed to evaluate the effect of encapsulated versus non-encapsulated CA4P. The efficiency of a treatment combining the magnetic targeting of CA4P-UML with the CA4P release triggered by HIFU was studied in CT26 murine tumors. Tumor perfusion and volume regression parameters were monitored by multiparametric quantitative anatomical and dynamic in vivo MRI at 7 T. A...Continue Reading

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Citations

Jul 31, 2020·Biomolecules·Paulina PecynaMalgorzata Kucinska
Jan 23, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Duoyi ZhaoXuesi Chen
Oct 4, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xiaoxuan MaiTianfeng Chen
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