Theranostic nanosensitizers for highly efficient MR/fluorescence imaging-guided sonodynamic therapy of gliomas

Journal of Cellular and Molecular Medicine
Hongmei LiuHairong Zheng

Abstract

Glioma is the most frequent primary brain tumour of the central nervous system. Its high aggressiveness and deep-seated brain lesion make it a great challenge to develop a non-invasive, precise and effective treatment approach. Here, we report a multifunctional theranostic agent that can integrate imaging and therapy into a single nano-platform for imaging-guided sonodynamic therapy (SDT). The SDT agents were fabricated by encapsulation of sinoporphyrin sodium (DVDMS) chelating with manganese ions into nanoliposomes (DVDMS-Mn-LPs). DVDMS-Mn-LPs are physiologically stable and biologically compatible, and they can produce singlet oxygen upon ultrasound irradiation to kill cancer cells. Both cell and animal studies demonstrated that SDT with DVDMS-Mn-LPs can significantly improve the antitumour growth efficiency even in the presence of skull. In addition, DVDMS-Mn-LPs are good for MR and fluorescence imaging. Thus, DVDMS-Mn-LPs reported here may provide a promising strategy for imaging-guided modality for glioma treatment.

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Citations

Jul 4, 2019·Angewandte Chemie·Xiahui LinHuanghao Yang
Jun 6, 2020·Journal of Neuro-oncology·Francesco PradaZhiyuan Xu
Mar 3, 2020·Frontiers in Pharmacology·Bingjie MaiPan Wang
Jan 6, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·David M StevensStephan T Stern
Apr 4, 2021·Journal of Clinical Medicine·Antonio D'AmmandoFrancesco Prada
Jul 3, 2021·International Journal of Molecular Sciences·Ruslan KashapovOleg Sinyashin

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Methods Mentioned

BETA
AFM
dynamic light scattering
atomic emission spectroscopy
irradiate
Fluorescence
flow cytometry
fluorescence imaging

Software Mentioned

Magnevist
CFlow Plus
IVIS Spectrum

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