Theranostic Performance of Acoustic Nanodroplet Vaporization-Generated Bubbles in Tumor Intertissue

Theranostics
Yi-Ju Ho, Chih-Kuang Yeh

Abstract

Solid tumors with poorly perfused regions reveal some of the treatment limitations that restrict drug delivery and therapeutic efficacy. Acoustic droplet vaporization (ADV) has been applied to directly disrupt vessels and release nanodroplets, ADV-generated bubbles (ADV-Bs), and drugs into tumor tissue. In this study, we investigated thein vivobehavior of ADV-Bs stimulated by US, and evaluated the possibility of moving intertissue ADV-Bs into the poorly perfused regions of solid tumors. Intravital imaging revealed intertissue ADV-B formation, movement, and cavitation triggered by US, where the distance of intertissue ADV-B movement was 33-99 µm per pulse. When ADV-Bs were applied to tumor cells, the cell membrane was damaged, increasing cellular permeability or inducing cell death. The poorly perfused regions within solid tumors show enhancement due to ADV-B accumulation after application of US-triggered ADV-B. The intratumoral nanodroplet or ADV-B distribution around the poorly perfused regions with tumor necrosis or hypoxia were demonstrated by histological assessment. ADV-B formation, movement and cavitation could induce cell membrane damage by mechanical force providing a mechanism to overcome treatment limitations in poorl...Continue Reading

Citations

Dec 24, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chao YangHaitao Ran
Aug 9, 2019·BioMed Research International·Ksenia LoskutovaMorteza Ghorbani
Sep 21, 2019·ACS Nano·Lichan ChenJibin Song
May 3, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Yosra ToumiaGaio Paradossi

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Methods Mentioned

BETA
dynamic light scattering

Software Mentioned

SPSS
MATLAB
Nanosight
ImageJ

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