Theranostic polymeric nanoparticles for NIR imaging and photodynamic therapy

International Journal of Pharmaceutics
E Tugce SarcanA Yekta Ozer

Abstract

Near-Infrared (NIR) dyes forming some of the photosensitizer agents show imaging and therapy features by themselves. NIR dyes show photodynamic therapy by formation of reactive oxygen species and imaging by NIR Fluorescence light. Photodynamic therapy occurs from irradiation of laser or light to photosensitizer matters and following by the formation of reactive oxygen species diseased tissues or cells can be killed effectively. NIR dyes have advantages such as stability, high specificity and sensitivity when compared with the other photosensitizer and imaging agents. Drug delivery systems are getting attention for either diagnosis or therapy of almost all of the diseases. Theranostic nanoparticles comprise the substances which shows the imaging and treatment features together. Besides, the combination of active substance and the imaging agent can also be encapsulated in theranostic nanoparticles. Many researchs are performed to evaluate the efficacy of theranostic drug delivery systems particularly polymeric nanoparticles in order to enhance targeting properties, specificity and bioavailability. Polymeric nanoparticles give advantages because of easier degradation properties when compared with the others. Theranostic polymeric ...Continue Reading

Citations

Mar 21, 2019·Drug Development Research·Mine Silindir-GunayAsuman Yekta Ozer
Nov 30, 2018·Journal of Clinical Medicine·Daniel Mihai TeleanuRaluca Ioana Teleanu
Aug 7, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Alexey V ErmakovGleb B Sukhorukov
Jan 23, 2021·RSC Medicinal Chemistry·Qizhi ZhangYunmei Liu
Feb 23, 2021·Frontiers in Pharmacology·Agnese GagliardiDonato Cosco
Nov 20, 2020·Drug Discovery Today·Ranjita Misra, Sarbari Acharya
Jul 23, 2021·International Journal of Pharmaceutics·Alexandro AzevedoHenrique Faneca
Jul 3, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Tânia AlbuquerqueDiana Costa
Jan 23, 2020·Current Medicinal Chemistry·Amanda Letícia Polli SilvestreMarlus Chorilli

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