Theranostic tumor homing nanocarriers for the treatment of lung cancer

Nanomedicine : Nanotechnology, Biology, and Medicine
Apurva R PatelMandip S Singh

Abstract

The drugs/strategies to selectively inhibit tumor blood supply have generated interest in recent years for enhancement of cancer therapeutics. The objective of this study was to formulate tumor homing PEGylated CREKA peptide conjugated theranostic nanoparticles of DIM-C-pPhC6H5 (DIM-P) and investigate in vivo antitumor activity as well as evaluate the targeted efficiency to lung tumors using imaging techniques. DIM-P loaded Nanoparticles (NCs-D) were prepared using lipids, and DOGS-NTA-Ni and the surface of NCs-D were modified with PEGylated CREKA peptide (PCNCs-D). PCNCs-D showed 3 fold higher binding to clotted plasma proteins in tumor vasculature compared to NCs-D. PCNCs-D showed 26%±4% and 22%±5% increase in tumor reduction compared to NCs-D in metastatic and orthotopic models respectively. In-vivo imaging studies showed ~40 folds higher migration of PCNCs-Di in tumor vasculature than NCs-Di. Our studies demonstrate the role of PCNCs-D as theranostic tumor homing drug delivery and imaging systems for lung cancer diagnosis and treatment. This study demonstrates a very efficient delivery system to address lung cancer growth through blood supply inhibition.

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Citations

Oct 17, 2015·Nanomedicine·Deniz Ali Bölükbas, Silke Meiners
Jun 4, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Bhuvaneshwar Vaidya, Vivek Gupta
Aug 5, 2015·Chemical Society Reviews·Magdiel Inggrid SetyawatiDavid Tai Leong
Aug 20, 2015·Pharmaceutical Research·Chandraiah GoduguMandip Singh
Sep 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Haisheng PengQun Wang
Jun 1, 2021·Biochimica Et Biophysica Acta. General Subjects·Md RizwanullahJaved Ahmad

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