Therapeutic advances in cutaneous T-cell lymphoma (CTCL): from retinoids to rexinoids

Seminars in Oncology
Rudolf Stadler, Almut Kremer

Abstract

Retinoids comprise a family of polyisoprenoid lipids that include vitamin A (retinol) and its various natural and synthetic analogues. Retinoids are compounds with multiple actions. They are involved in the control of cell proliferation, cell differentiation, and embryonic development. Each retinoid has its own profile of pharmacologic properties that determines its usefulness in clinical dermatology or oncology. Although numerous synthetic retinoids have been synthesized, their biological activities are usually associated with clinical disadvantages such as toxicity and teratogenicity. Retinoids that bind to both the retinoic acid receptor and retinoid X receptor subtypes have shown clinical activity in hematologic malignancies and can mediate genes associated with both growth and differentiation. Retinoid X receptor-specific rexinoids have also shown efficacy in the treatment of cutaneous T-cell lymphomas, but their exact mechanism of action is unclear. This article summarizes the clinical relevance of both groups of compounds in this important patient population.

References

Jan 1, 1987·Dermatologica·G Mahrle, B Thiele
Oct 25, 2003·Journal of the American Academy of Dermatology·Peter HealdUNKNOWN Worldwide Bexarotene Study Group
Apr 2, 2004·Expert Review of Anticancer Therapy·Len T Farol, Kenneth B Hymes
Jul 9, 2004·Dermatology : International Journal for Clinical and Investigative Dermatology·S MichaelisR Dummer
Jul 10, 2004·Journal of the American Academy of Dermatology·Christiane QuerfeldTimothy M Kuzel
Sep 25, 2004·Journal of the American Academy of Dermatology·Fiza Singh, Mark G Lebwohl

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Citations

Aug 23, 2006·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·R Stadler
Apr 10, 2008·PloS One·Chetana SachidanandanRandall T Peterson
Jun 8, 2007·The British Journal of Dermatology·R GniadeckiS Whittaker
Mar 12, 2011·Photodermatology, Photoimmunology & Photomedicine·Franz Trautinger
Oct 5, 2015·Dermatologic Clinics·Auris O Huen, Ellen J Kim
Sep 2, 2014·The Veterinary Clinics of North America. Small Animal Practice·Donna M Raditic, Joseph W Bartges
Apr 19, 2007·The Journal of Clinical Endocrinology and Metabolism·Johannes W A SmitTheo J Visser
Mar 28, 2007·Cancer Control : Journal of the Moffitt Cancer Center·Dorna RezaniaHernani D Cualing

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