Therapeutic and immunomodulatory effects of glucosamine in combination with low-dose cyclosporine a in a murine model of imiquimod-induced psoriasis

European Journal of Pharmacology
Chang-Hyun KimAi-Young Lee

Abstract

Although cyclosporine A (CsA) is a potent immunomodulating agent and is commonly used as a systemic agent for the management of psoriasis patients, current clinical treatments are not always effective due to the clinical inefficacy of low-doses and numerous harmful effects of higher doses. Currently, the combined use of two other systemic drugs often has better therapeutic efficacy and is safer than low or high dose of a single drug. Glucosamine (Glu) also has immunomodulatory properties for autoimmune diseases. The aims of our study were to investigate the therapeutic efficacy of Glu in combination with low-dose CsA on imiquimod (IMQ)-induced psoriasis-like dermatitis in mice and to determine its immunomodulatory mechanism. We found that combined treatment with Glu (300 mg/kg) and low-dose (10 or 20mg/kg) CsA strongly ameliorated the development of psoriasis-like skin lesions and reduced the levels of Th1 cytokine (TNF-α) and Th17 cytokines (IL-17, IL-22, and IL-23) in the serum and dorsal skin. Histological findings also showed that the thickening of epidermis, stratum corneum, and inflammatory cell infiltration. Particularly, these combined treatments increased the number of CD4(+)CD25(+) regulatory T (Treg) cells in splenic...Continue Reading

References

Dec 5, 2002·Clinical and Experimental Dermatology·N J Reynolds, W I Al-Daraji
Dec 18, 2003·Clinical and Experimental Immunology·J E GudjonssonH Valdimarsson
Jan 7, 2004·The Journal of Experimental Medicine·Edmund LeeJames G Krueger
Dec 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hideaki SugiyamaKevin D Cooper
Nov 23, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guang-Xian ZhangAbdolmohamad Rostami
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gamze PiskinMarcel B M Teunissen
Feb 23, 2007·Nature·Michelle A LowesJames G Krueger
Jul 31, 2007·Lancet·Christopher Em Griffiths, Jonathan Nwn Barker
Nov 28, 2007·The Journal of Experimental Medicine·Lisa C ZabaJames G Krueger
Jan 19, 2008·The Journal of Clinical Investigation·Hak-Ling MaDeborah A Young
Aug 13, 2008·Expert Opinion on Therapeutic Targets·Francesca FantuzziGiampiero Girolomoni
Apr 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Leslie van der FitsErik Lubberts
Jul 31, 2009·The New England Journal of Medicine·Frank O NestleJonathan Barker
Feb 24, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·E J HornUNKNOWN International Psoriasis Council
Jun 25, 2010·Acta Dermato-venereologica·Peter JensenClaus Zachariae
Mar 17, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·C PaulJ-P Ortonne
Dec 2, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Astrid B Van BelleLaure Dumoutier
Dec 14, 2011·The Journal of Investigative Dermatology·Karin Loser, Stefan Beissert
Jun 19, 2012·Cellular & Molecular Immunology·Yihua CaiJun Yan
Jul 25, 2012·Current Opinion in Allergy and Clinical Immunology·Christina E ZielinskiMarcus Maurer
Sep 11, 2012·Journal of Leukocyte Biology·M Merle EllosoAnne M Fourie
Feb 15, 2013·The Journal of Investigative Dermatology·Mireia Uribe-HerranzLiselotte E Jensen
May 7, 2013·Journal of Dermatological Science·Katrin SchaperWolfgang Bäumer
Jul 11, 2013·Clinical and Experimental Dermatology·S Dogra, R Mahajan
Nov 21, 2013·European Journal of Immunology·Barry Flutter, Frank O Nestle
Mar 25, 2014·Annual Review of Immunology·Michelle A LowesJames G Krueger
Mar 25, 2014·Journal of the American Academy of Dermatology·Charles W LyndeSam Khalil
Jun 26, 2014·Dermatologic Therapy·Katerina DamevskaSilvia Duma
Sep 5, 2014·JAMA Dermatology·Celine BusardPhyllis I Spuls

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Citations

Mar 31, 2016·Clinical Reviews in Allergy & Immunology·Yaxiong DengQianjin Lu
Jan 11, 2018·International Journal of Molecular Sciences·Andrea ChiricozziMarco Romanelli
Jan 3, 2018·International Journal of Molecular Sciences·Xuan Xu, Hong-Yu Zhang
Mar 1, 2019·Tissue Engineering and Regenerative Medicine·Chang-Hyun KimEun Ju Lee
Apr 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hsin-Hua ChenPo-Ying Lee
Apr 6, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Mingkwan Na TakuathungSeewaboon Sireeratawong
Mar 30, 2021·Journal of Pharmacological and Toxicological Methods·Christina KaramaniHoward Maibach

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