Therapeutic and Mechanistic Approaches of Tridax Procumbens Flavonoids for the Treatment of Osteoporosis.

Current Drug Targets
Abdul Alim Al-BariMd Abdullah Al Mamun

Abstract

Homeostasis of bone is closely regulated by the balanced activities between the bone resorbing activity of osteoclast cells and bone-forming ability of osteoblast cells. Multinucleated osteoclasts degrade bone matrix and involve in the dynamic bone remodelling in coordination with osteoblasts. Disruption of this regulatory balance between these cells or any imbalance in bone remodelling caused by a higher rate of resorption over construction of bone results in a decrease of bone matrix including bone mineral density (BMD). These osteoclast-dominant effects result in a higher risk of bone crack and joint demolition in several bone-related diseases, including osteoporosis and rheumatoid arthritis (RA). Tridax procumbens is a very interesting perennial plant and its secondary metabolites called here T. procumbens flavonoids (TPFs) are well-known phytochemical agents owing to various therapeutic practices such as anti-inflammatory, anti-anaemic and anti-diabetic actions. This review designed to focus the systematic convention concerning the medicinal property and mechanism of actions of TPFs for the management of bone-related diseases. Based on the current literature, the review offers evidence-based information of TPFs for basic r...Continue Reading

References

Apr 1, 1996·Physiological Reviews·G S SteinM Montecino
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·H YasudaT Suda
Jan 20, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S GronthosP J Simmons
Apr 2, 1999·Science·M F PittengerD R Marshak
Jul 28, 1999·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·A NaitoJ Inoue
Feb 23, 2000·The Journal of Clinical Investigation·K P McHughS L Teitelbaum
Aug 10, 2000·The American Journal of Pathology·D L LaceyA J Polverino
Sep 1, 2000·Science·S L Teitelbaum
Sep 1, 2000·Science·G A Rodan, T J Martin
Feb 24, 2001·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·A Taddei, A J Rosas-Romero
Oct 31, 2001·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·K ShirakabeE Nishida
Feb 28, 2002·Annual Review of Immunology·Lars E TheillJosef M Penninger
Apr 24, 2002·Developmental Cell·Gerard Karsenty, Erwin F Wagner
Jun 11, 2002·Annual Review of Nutrition·Julie A Ross, Christine M Kasum
Aug 10, 2002·Natural Product Letters·Muhammad Shaiq Ali, Muhammad Jahangir
Nov 25, 2003·The EMBO Journal·David G WinklerJohn A Latham
Apr 10, 2004·The Journal of Biological Chemistry·Koichi MatsuoErwin F Wagner
Apr 22, 2004·Journal of Ethnopharmacology·Umesh TiwariSuresh P Vyas
Sep 18, 2004·Histology and Histopathology·T C A PhanM H Zheng
Mar 24, 2005·Journal of Cellular Biochemistry·Ayse B CelilPhil G Campbell
Jun 2, 2005·The Journal of Experimental Medicine·Sebastian StierDavid T Scadden
Jun 11, 2005·Bone·Hansjoerg Keller, Michaela Kneissel
Sep 27, 2005·The Journal of Clinical Investigation·Shuting BaiSteven L Teitelbaum
Nov 9, 2005·The Journal of Experimental Medicine·Masataka AsagiriHiroshi Takayanagi
Nov 29, 2005·Endocrinology and Metabolism Clinics of North America·Sundeep Khosla, B Lawrence Riggs
Nov 30, 2005·Immunological Reviews·F Patrick Ross, Steven L Teitelbaum
Sep 1, 2006·European Journal of Clinical Nutrition·A A MulliganS A Bingham
Sep 20, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·O Johnell, J A Kanis

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Citations

Oct 17, 2020·Scientific Reports·Yunyao LuoLiangzhi Xu

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