Therapeutic angiogenesis in diabetic apolipoprotein E-deficient mice using bone marrow cells, functional hemangioblasts and metabolic intervention

Atherosclerosis
Maria Luisa BalestrieriClaudio Napoli

Abstract

Peripheral arterial disease (PAD) is a major health problem especially when associated to concomitant diabetes and hypercholesterolemia. Hyperglycemia with an overwhelming generation of oxygen radicals and formation of glycation end-products exacerbates oxidation-sensitive mechanisms activated by tissue ischemia. Administration of autologous bone marrow cells (BMC) is an increasing notable intervention to induce therapeutic angiogenesis, ameliorated by metabolic intervention (MT). Recently, hemangioblasts (HS) with functional properties were isolated. The effects of integrate regimen with intravenous BMC, HS, and MT (1.0% vitamin E, 0.05% vitamin C, and 6% l-arginine) were examined in the ischemic hindlimb of ApoE(-/-) diabetic and non-diabetic. Blood flow ratio was monitored by use of a laser Doppler blood flowmeter. Capillary density was determined in sections of the adductor and semimembranous muscles with antibody against CD31. BMC or HS alone, and BMC plus HS increased blood flow and capillary densities and decreased interstitial fibrosis. These effects were amplified by additional MT, at least in part, through the nitric oxide pathway, reduction of systemic oxidative stress and macrophage infiltration. Investigation of mo...Continue Reading

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Citations

Dec 4, 2010·Atherosclerosis·Claudio NapoliLouis J Ignarro
Mar 4, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Nian Cao, Zhong-Xiang Yao
Nov 12, 2014·Clinical Physiology and Functional Imaging·Vincenzo GrimaldiClaudio Napoli
Jul 10, 2013·Journal of cardiology·Vincenzo GrimaldiClaudio Napoli
Nov 28, 2012·Atherosclerosis·Shamim LotfiBijan Modarai
Aug 17, 2011·Stem Cells International·Amer MahmoodAbdullah Aldahmash
May 15, 2013·Journal of the American College of Cardiology·Claudio NapoliLouis J Ignarro

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