Therapeutic Angiogenesis of Chinese Herbal Medicines in Ischemic Heart Disease: A Review

Frontiers in Pharmacology
Dongqing GuoXing Chen

Abstract

Ischemic heart disease (IHD) is one of the primary causes of death around the world. Therapeutic angiogenesis is a promising innovative approach for treating IHD, improving cardiac function by promoting blood perfusion to the ischemic myocardium. This treatment is especially important for targeting patients that are unable to undergo angioplasty or bypass surgery. Chinese herbal medicines have been used for more than 2,500 years and they play an important role alongside contemporary medicines in China. Growing evidence in animal models show Chinese herbal medicines can provide therapeutic effect on IHD by targeting angiogenesis. Identifying the mechanism in which Chinese herbal medicines can promote angiogenesis in IHD is a major topic in the field of traditional Chinese medicine, and has the potential for advancing therapeutic treatment. This review summarizes the progression of research and highlights potential pro-angiogenic mechanisms of Chinese herbal medicines in IHD. In addition, an outline of the limitations of Chinese herbal medicines and challenges they face will be presented.

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Citations

Jul 26, 2019·Current Hypertension Reports·Sayuri PadayacheeThajasvarie Naicker
Jun 11, 2019·Oxidative Medicine and Cellular Longevity·Dehai XianJianqiao Zhong
Aug 9, 2020·Tissue Engineering. Part a·May-Hui DingSue Anne Chew
Apr 20, 2021·Frontiers in Cell and Developmental Biology·Guoyang ZhouLin Wang
Jul 27, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Yueming LuoMeizhen Lin
Aug 31, 2021·Annals of Medicine and Surgery·Mendy Hatibie OleyMuhammad Faruk

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Methods Mentioned

BETA
coronary artery bypass
chip

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