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Therapeutic antibody targeting microtubule-binding domain prevents neuronal internalization of extracellular tau via masking neuron surface proteoglycans

Acta Neuropathologica Communications

Aug 7, 2019

Petronela WeisovaMichal Novak

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Abstract

Pathologically altered tau protein is a common denominator of neurodegenerative disorders including Alzheimer's disease (AD) and other tauopathies. Therefore, promising immunotherapeutic approaches target and eliminate extracellular pathogenic tau species, which are thought to be respon...read more

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Alzheimer's Disease
Monoclonal Antibodies
Epitopes
Laboratory mice
Microtubules
Neurons
Pathologic Processes
Pathology
Proteoglycan
Heparan Sulfate Proteoglycans
2
11
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Therapeutic antibody targeting microtubule-binding domain prevents neuronal internalization of extracellular tau via masking neuron surface proteoglycans

Acta Neuropathologica Communications

Aug 7, 2019

Petronela WeisovaMichal Novak

PMID: 31391090

DOI: 10.1186/s40478-019-0770-y

Abstract

Pathologically altered tau protein is a common denominator of neurodegenerative disorders including Alzheimer's disease (AD) and other tauopathies. Therefore, promising immunotherapeutic approaches target and eliminate extracellular pathogenic tau species, which are thought to be respon...read more

Mentioned in this Paper

Alzheimer's Disease
Monoclonal Antibodies
Epitopes
Laboratory mice
Microtubules
2
11

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