Therapeutic application of natural inhibitors against snake venom phospholipase A(2).

Bioinformation
Ramar Perumal SamyVincent Tk Chow

Abstract

Natural inhibitors occupy an important place in the potential to neutralize the toxic effects caused by snake venom proteins and enzymes. It has been well recognized for several years that animal sera, some of the plant and marine extracts are the most potent in neutralizing snake venom phospholipase A(2) (svPLA(2)). The implication of this review to update the latest research work which has been accomplished with svPLA(2) inhibitors from various natural sources like animal, marine organisms presents a compilation of research in this field over the past decade and revisiting the previous research report including those found in plants. In addition to that the bioactive compounds/inhibitor molecules from diverse sources like aristolochic alkaloid, flavonoids and neoflavonoids from plants, hydrocarbones -2, 4 dimethyl hexane, 2 methylnonane, and 2, 6 dimethyl heptane obtained from traditional medicinal plants Tragia involucrata (Euphorbiaceae) member of natural products involved for the inhibitory potential of phospholipase A(2) (PLA(2)) enzymes in vitro and also decrease both oedema induced by snake venom as well as human synovial fluid PLA(2). Besides marine natural products that inhibit PLA(2) are manoalide and its derivatives...Continue Reading

Citations

Sep 26, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·P A ShenoyP D Chaudhari
Feb 7, 2013·Natural Product Reports·Lishu WangYonghong Liu
Oct 1, 2015·Journal of Receptor and Signal Transduction Research·Sathishkumar ChinnasamyKarthikeyan Muthusamy
Jan 22, 2013·Toxicon : Official Journal of the International Society on Toxinology·Ayse NalbantsoyNefise Ülkü Karabay Yavaşoğlu
Feb 11, 2014·BioMed Research International·Eduardo Coriolano De OliveiraAndré Lopes Fuly
Oct 31, 2013·BioMed Research International·B M A CarvalhoD P Marchi-Salvador
Oct 12, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eduardo Coriolano de OliveiraAndré Lopes Fuly
Sep 15, 2017·International Journal of Molecular Sciences·Cinthia I TamayoseMarcos H Toyama
Jan 11, 2018·BioMed Research International·Huixiang XiaoChunhong Huang
Sep 12, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Isabel Gómez-BetancurFrancisco León
Aug 9, 2018·Journal of Pharmacopuncture·Pushpendra SinghRahul Shrivastava
Aug 30, 2018·Journal of Tropical Medicine·Tommaso C BulfoneMatthew R Lewin
Jan 1, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Mumtaz S PallieCharitha L Goonasekara
Jun 25, 2021·Journal of Chemical Ecology·Caroline Fabri Bittencourt RodriguesBryan Grieg Fry

❮ Previous
Next ❯

Methods Mentioned

BETA
NMR
X-ray
Xray
chemical
amputation

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

Toxicon : Official Journal of the International Society on Toxinology
Maung-Maung ThwinPonnampalam Gopalakrishnakone
Toxicon : Official Journal of the International Society on Toxinology
Guillermo LeónJosé María Gutiérrez
Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP
Deepa K MachiahThere V Gowda
© 2022 Meta ULC. All rights reserved