Therapeutic applications of adipose cell-free derivatives: a review.

Stem Cell Research & Therapy
Yuan CaiChengliang Deng

Abstract

Adipose-derived stem cells (ADSCs) have become one of the most utilized adult stem cells due to their abundance and accessibility. Recent studies have shown that paracrine cytokines, exosomes, and other active substances are the main factors through which ADSCs exert their biological effects. Adipose cell-free derivatives have been recently gaining attention as potential therapeutic agents for various human diseases. These derivatives include ADSC-conditioned medium (ADSC-CM), ADSC exosomes (ADSC-Exo), and cell-free adipose tissue extracts (ATEs), all of which can be conveniently carried, stored, and transported. Currently, research on ADSC-conditioned medium (ADSC-CM) and ADSC exosomes (ADSC-Exo) is surging. Moreover, cell-free adipose tissue extracts (ATEs), obtained by purely physical methods, have emerged as the focus of research in recent years. Adipose cell-free derivatives delivery can promote cell proliferation, migration, and angiogenesis, suppress cell apoptosis, and inflammation, as well as reduce oxidative stress and immune regulation. Thus, adipose cell-free derivatives have a broad therapeutic potential in many areas, as they possess anti-skin aging properties, promote wound healing, reduce scar formation, and pro...Continue Reading

References

Apr 16, 2005·Neuro-oncology·Balveen KaurErwin G Van Meir
Jul 21, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Eun Young LeeJong-Hyuk Sung
Nov 28, 2009·Current Stem Cell Research & Therapy·António J Braga Osório Gomes SalgadoJeffrey M Gimble
Dec 2, 2009·Molecular and Cellular Endocrinology·Kalypso Karastergiou, Vidya Mohamed-Ali
Dec 23, 2009·Molecular and Cellular Endocrinology·Sylvia P PoulosGary J Hausman
Sep 10, 2011·Tissue Engineering. Part a·Jertta-Riina SarkanenTimo Ylikomi
Mar 1, 2012·Seminars in Cardiothoracic and Vascular Anesthesia·Anja FrankTobias Eckle
Apr 27, 2012·Journal of Neuroscience Research·Yu Jin ChoKyeung Min Joo
Jan 16, 2013·Biochemical and Biophysical Research Communications·Lijuan ChenYaoliang Tang
Jan 11, 2014·Stem Cell Research & Therapy·Giovanni Di BernardoUmberto Galderisi
Oct 2, 2015·Cell Transplantation·Tiziana SquillaroUmberto Galderisi
Jan 7, 2016·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Bing-Rong ZhouDan Luo
Mar 11, 2016·Aesthetic Surgery Journal·Elizabeth R ZielinsDerrick C Wan
Apr 2, 2016·The Journal of Clinical Investigation·Rong XuRichard J Simpson
May 15, 2016·The European Journal of Neuroscience·Mijung LeeManho Kim
Jul 23, 2016·British Journal of Pharmacology·Anandharajan RathinasabapathyMichael J Katovich
Sep 20, 2016·Biochemical and Biophysical Research Communications·Mijung LeeManho Kim
Sep 24, 2016·Scientific Reports·Wataru NakaiRikinari Hanayama
Feb 1, 2017·Biochemical and Biophysical Research Communications·You Kyung NaManho Kim
Aug 26, 2017·International Journal of Molecular Sciences·Francisco J VizosoRoman Perez-Fernandez
Sep 1, 2017·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Min Ho KimJong Hun Lee
Nov 29, 2017·The AAPS Journal·Anjana Jeyaram, Steven M Jay
Dec 15, 2017·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Chengliang DengLu Feng
Dec 29, 2017·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Xi WangLi Li
Feb 3, 2018·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Farshad Zarei, Abolfazl Abbaszadeh
Feb 23, 2018·Stem Cell Research & Therapy·Xiuxia WangJun Yang
Apr 18, 2018·BioMed Research International·Maria Yu KonoshenkoPavel P Laktionov
Jun 2, 2018·Connective Tissue Research·Yan ZhangWeidong Tian

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Citations

Oct 25, 2020·Stem Cell Research & Therapy·Angelo TrivisonnoGabriele Toietta
Jun 2, 2021·Journal of Translational Medicine·Loubna MaziniGabriel Malka
May 29, 2021·World Journal of Clinical Cases·Sheng-Yang ZhangPei-Jian Tong
Jun 22, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Changlin LianHongbo Guo
Jul 9, 2021·Expert Opinion on Biological Therapy·Gerhard Hamilton, Maryana Teufelsbauer
Aug 28, 2021·Archives of Gerontology and Geriatrics·Lintao LiJingchuan Sun

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Methods Mentioned

BETA
bronchoalveolar lavage

Software Mentioned

CM
Exo
ADSC

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