Therapeutic Applications of Curcumin Nanoformulations

The AAPS Journal
Murali M YallapuSubhash C Chauhan

Abstract

Curcumin (diferuloylmethane) is a bioactive and major phenolic component of turmeric derived from the rhizomes of curcuma longa linn. For centuries, curcumin has exhibited excellent therapeutic benefits in various diseases. Owing to its anti-oxidant and anti-inflammatory properties, curcumin plays a significant beneficial and pleiotropic regulatory role in various pathological conditions including cancer, cardiovascular disease, Alzheimer's disease, inflammatory disorders, neurological disorders, and so on. Despite such phenomenal advances in medicinal applications, the clinical implication of native curcumin is hindered due to low solubility, physico-chemical instability, poor bioavailability, rapid metabolism, and poor pharmacokinetics. However, these issues can be overcome by utilizing an efficient delivery system. Active scientific research was initiated in 2005 to improve curcumin's pharmacokinetics, systemic bioavailability, and biological activity by encapsulating or by loading curcumin into nanoform(s) (nanoformulations). A significant number of nanoformulations exist that can be translated toward medicinal use upon successful completion of pre-clinical and human clinical trials. Considering this perspective, current re...Continue Reading

References

Apr 24, 2004·Science·Marie E EganMichael J Caplan
Jan 18, 2006·Life Sciences·Radha K MaheshwariRikhab C Srimal
Jan 21, 2006·The Journal of Pharmacology and Experimental Therapeutics·Joanna LipeckaNoélie Davezac
Feb 9, 2007·International Journal of Pharmaceutics·Waree TiyaboonchaiPinyupa Plianbangchang
Apr 19, 2007·Journal of Nanobiotechnology·Savita BishtAnirban Maitra
Jun 16, 2007·Advances in Experimental Medicine and Biology·Bharat B AggarwalHaruyo Ichikawa
Nov 15, 2007·Molecular Pharmaceutics·Preetha AnandBharat B Aggarwal
Jun 14, 2008·Molecular Nutrition & Food Research·Chung S YangMao-Jung Lee
Jun 6, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Rohit MulikAnant Paradkar
Oct 16, 2009·International Journal of Cancer. Journal International Du Cancer·Estefanía Burgos-MorónMiguel López-Lázaro
Nov 6, 2009·Molecular Pharmaceutics·Malgorzata S CartieraW Mark Saltzman
Mar 6, 2010·Journal of Biomedical Nanotechnology·Dandekar PrajaktaPatravale Vandana
May 12, 2010·Colloids and Surfaces. B, Biointerfaces·Murali Mohan YallapuSubhash C Chauhan
Jun 24, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Dongmei SunHuang-Ge Zhang
Jul 10, 2010·Nature Reviews. Drug Discovery·Robby A Petros, Joseph M DeSimone
Aug 7, 2010·Colloids and Surfaces. B, Biointerfaces·Aditya P NayakEliana B Souto
Sep 17, 2010·Pharmaceutical Research·Murali Mohan YallapuVinod Labhasetwar
Oct 22, 2010·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Parthiban SelvamHugh D C Smyth
Nov 9, 2010·Cell Transplantation·Arun KumarDon F Cameron
Dec 7, 2010·Biomaterials·Spyridon MourtasSophia G Antimisiaris
Dec 21, 2010·Biomaterials·Murali M YallapuSubhash C Chauhan
Feb 17, 2011·Journal of Agricultural and Food Chemistry· BhawanaNidhi Jain
May 7, 2011·Cancer Prevention Research·Shyam S BansalRamesh C Gupta
Jan 18, 2010·Macromolecular Rapid Communications·Wei ChenNicholas A Kotov
May 31, 2011·Biotechnology Advances·Feroz AkhtarSantosh Kumar Kar
Jul 5, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Mark TaylorDavid Allsop
Sep 6, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Vandita Kakkar, Indu Pal Kaur
Oct 1, 2011·Drug Discovery Today·Murali M YallapuSubhash C Chauhan
Dec 7, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Benedetta IsacchiAnna Rita Bilia
Jan 12, 2012·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·N SuwannateepM C Meinke
Mar 20, 2012·Journal of Alzheimer's Disease : JAD·Sihem DogguiCharles Ramassamy

❮ Previous
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Citations

Jul 10, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Giuseppe DerosaAmirhossein Sahebkar
Jul 13, 2016·European Journal of Pharmacology·Guddadarangavvanahally K JayaprakashaBhimanagouda S Patil
Nov 7, 2016·Drug Discovery Today·Aditya GanjuMeena Jaggi
Nov 9, 2016·Neuroscience and Biobehavioral Reviews·Rosa Anna VaccaSeyed Mohammad Nabavi
Jan 24, 2017·Journal of Agricultural and Food Chemistry·Maria Luisa BondìMelchiorre Cervello
May 13, 2017·International Journal of Pharmaceutics·Ruozi BarbaraAndreas M Grabrucker
May 19, 2017·Journal of the Science of Food and Agriculture·Pei Shan LuBing Huei Chen
Feb 3, 2018·International Journal of Molecular Sciences·Claire M Pfeffer, Amareshwar T K Singh
Mar 10, 2020·International Journal of Radiation Biology·Shilpa JohnsonYashodhar P Bhandary
Mar 14, 2020·Journal of Clinical Medicine·Bahare SalehiJavad Sharifi-Rad
Apr 10, 2020·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Zahra Matloubi, Zuhair Hassan
Aug 19, 2020·Journal of Biomaterials Applications·Reza MahmoudiHassan Bardania
Aug 26, 2020·Bioscience, Biotechnology, and Biochemistry·Hiroshi EndoMihiro Yano
Apr 24, 2020·Current Pharmaceutical Design·Anmol DograJasjeet K Narang
Aug 31, 2020·Journal of Biochemical and Molecular Toxicology·Sruthi Sritharan, Nageswaran Sivalingam
Mar 30, 2017·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Mari Anoushka Ricker, William Christian Haas
Feb 27, 2019·Recent Patents on Drug Delivery & Formulation·Himangshu SarmaHemanta K Sharma
Mar 21, 2019·Frontiers in Pharmacology·Kar En WongLay-Hong Chuah
Mar 27, 2020·International Journal of Molecular Sciences·Saikat DewanjeeVincenzo De Feo
Jun 17, 2020·Chemical Society Reviews·Saeid KargozarMasoud Mozafari
Dec 6, 2018·International Journal of Molecular Sciences·Daniela ChirioMarina Gallarate
Aug 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Arturo SánchezJahir Orozco
May 21, 2019·Journal of Microencapsulation·Zaynab Sadeghi Ghadi, Pedram Ebrahimnejad
Aug 9, 2020·Oxidative Medicine and Cellular Longevity·Nathan Earl RaineyPatrice Xavier Petit
Apr 30, 2020·Current Drug Metabolism·Beatriz Agame-LagunesHugo Sergio García
Dec 29, 2016·International Journal of Environmental Research and Public Health·Yu-Nong ChenLi-Chen Wu
Feb 17, 2017·European Journal of Nutrition·Martin PurpuraValentina Razmovski-Naumovski
Aug 16, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Raghavendhar R Kotha, Devanand L Luthria
May 20, 2020·Frontiers in Pharmacology·Adhimoolam KarthikeyanTaesun Min
Jul 2, 2019·Seminars in Cancer Biology·Eluri PavitraYun Suk Huh

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