Abstract
Postoperative anemia is a common finding in patients who undergo major surgery, and it can affect early rehabilitation and the return to daily activities. Allogeneic blood transfusion is still the most widely used method for restoring hemoglobin levels rapidly and effectively. However, the potential risks of transfusions have led to the review of this practice and to a search for alternative measures for treating postoperative anemia. The early administration of intravenous iron appears to improve the evolution of postoperative hemoglobin levels and reduce allogeneic transfusions, especially in patients with significant iron deficiency or anemia. What is not clear is whether this treatment heavily influences rehabilitation and quality of life. There is a lack of well-designed, sufficiently large, randomized prospective studies to determine whether postoperative or perioperative intravenous iron treatment, with or without recombinant erythropoietin, has a role in the recovery from postoperative anemia, in reducing transfusions and morbidity rates and in improving exercise capacity and quality of life.
References
Feb 14, 1998·The British Journal of Surgery·C E van IperenA van de Wiel
Aug 2, 2003·The American Journal of Medicine·Brenda W J H PenninxMarco Pahor
Mar 31, 2004·The American Journal of Medicine·Aryeh ShanderRichard Spence
Dec 24, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Keyvan KarkoutiTerrence M Yau
Dec 12, 2007·Vox Sanguinis·M MuñozE Bisbe
Mar 20, 2008·Anesthesia and Analgesia·Niamh P ConlonMaire McCarroll
Nov 27, 2008·Anesthesiology·Donat R SpahnJames P Isbister
Jul 16, 2010·Transfusion·José Antonio Serrano-TrenasPedro Carpintero Benítez
Aug 4, 2011·Transfusion·Elise Vuille-LessardJean-François Hardy
Dec 16, 2011·The New England Journal of Medicine·Jeffrey L CarsonUNKNOWN FOCUS Investigators
Feb 18, 2012·British Journal of Anaesthesia·M MuñozJ Cordero
Jan 29, 2013·Best Practice & Research. Clinical Anaesthesiology·Sumit SinghMitchell P Fink
Mar 20, 2013·Medicina intensiva·S R Leal-NovalUNKNOWN Sociedades Españolas de Anestesiología y Reanimación (SEDAR), Hematología y Hemoterapia (SEHH), Farmacia Hospitalaria (SEFH)
May 25, 2013·European Journal of Heart Failure·Josep Comín-ColetJordi Bruguera
May 28, 2013·Lancet·Donat R Spahn, Lawrence T Goodnough