Therapeutic Approaches to Atrophic Vaginitis in Postmenopausal Women: A Systematic Review with a Network Meta-analysis of Randomized Controlled Trials

Journal of Menopausal Medicine
Arum LeeKisung Song

Abstract

Atrophic vaginitis (AV), which is common in postmenopausal women, is characterized by vaginal dryness, dyspareunia, and discomfort. There are a variety of therapeutic agents for the treatment of AV, besides hormone replacement therapy. We performed this systematic review to compare the effectiveness of various therapies for symptom improvement in AV patients. We searched the Cochrane Library, EMBASE, MEDLINE, and other literature (Google Scholar, Web of Science, and hand search) for studies published between January 2010 and March 2015. AV was evaluated by the following outcomes: vaginal pH, dyspareunia, vaginal dryness, or cytological change (endometrial thickness, percentages of superficial cells and parabasal cells). They measured treatment efficacy with various outcomes pertaining to AV symptoms. Meta-analysis suggested that ospemifene was effective against dyspareunia, vaginal dryness, endometrial thickness, and percentage changes in superficial and parabasal cells. Vaginal pH was most affected by soy isoflavone vaginal gel. Ospemifene was effective for AV symptoms. This systematic review compared the effects of several therapeutic agents on symptoms of AV through a network meta-analysis. This study provides objective evid...Continue Reading

References

Apr 26, 2002·Menopause : the Journal of the North American Menopause Society·Richard J SantenKaren O Klein
Jan 26, 2013·Climacteric : the Journal of the International Menopause Society·U JaisamrarnN Taechakraichana
Jan 31, 2013·Menopause : the Journal of the North American Menopause Society·David J PortmanUNKNOWN Ospemifene Study Group
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Sep 12, 2015·Journal of Menopausal Medicine·Hyun-Kyung KimMee-Ran Kim
May 20, 2017·Journal of Menopausal Medicine·Seok Hwan KimTae Hee Kim
Sep 28, 2017·Journal of Menopausal Medicine·Jae Jun ShinChang Suk Suh

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Citations

Nov 9, 2019·Minerva ginecologica·Angelo CagnacciUNKNOWN Società Italiana della Menopausa (SIM) and the Società Italiana di Ginecologia della Terza Età (SIGiTE)
Mar 15, 2020·Journal of Sex & Marital Therapy·Parvin AbediGholamreza Houshmand
Apr 25, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Lino Del Pup, Rafael Sánchez-Borrego

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Methods Mentioned

BETA
hormone replacement therapy

Software Mentioned

WinBUGS
R

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