Therapeutic approaches to human immunodeficiency virus: structural studies on G-protein-coupled receptors

Pharmacology & Therapeutics
Garland R Marshall

Abstract

Infection by human immunodeficiency virus (HIV) requires the presence of a chemokine receptor on the susceptible cell. The expression of two different chemokine receptors on macrophages and lymphocytes explains the selectivity of different HIV isolates. The rationale behind the choice of the chemokine receptor (CCR5) expressed on macrophages as a therapeutic target is based on the epidemiological studies of the impact on HIV infectivity of a human mutation that prevents expression of this receptor. CCR5 is a member of the G-protein-coupled receptor family, which has yet to be characterized structurally at atomic resolution. Efforts to model the three-dimensional structure of such receptors and to characterize them experimentally are underway in many laboratories. As an example, structural studies determining the bound conformation of the C-terminal peptide of the alpha-subunit of transducin, the relevant G-protein of vision, with rhodopsin are presented.

References

May 20, 1993·Nature·E A DratzH E Hamm
Dec 29, 1995·The Journal of Biological Chemistry·S Osawa, E R Weiss
Jan 5, 1996·The Journal of Biological Chemistry·E L MartinH E Hamm
Jan 25, 1996·Nature·D G LambrightP B Sigler
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·L MoutouhD D Richman
Jan 1, 1996·Annual Review of Pharmacology and Toxicology·J W Erickson, S K Burt
Mar 1, 1996·Research in Virology·J S Friedland
Mar 7, 1997·The Journal of Biological Chemistry·S AcharyaS S Karnik
Feb 28, 1997·Science·J Cohen

❮ Previous
Next ❯

Citations

May 15, 2002·Veterinary Immunology and Immunopathology·Venu GangurSirinart Thanesvorakul

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.