Therapeutic benefits of glutamine: An umbrella review of meta-analyses

Biomedical Reports
Marc P McRae

Abstract

Glutamine may be an essential amino acid in patients with catabolic disease, as it has been demonstrated that circulating glutamine levels drop during critical illness and following major surgery; this may result in an increase in secondary infection risk, recovery time and mortality rates. However, there is much discrepancy in the literature with regards to randomized controlled studies, and therefore, the present study is an umbrella review of published meta-analyses, conducted to examine the effectiveness of glutamine's role as a therapeutic agent. A search using PubMed, Cochrane Library and CINAHL from January 1st, 1980 to December 31st, 2016 was conducted using the following strategy: 'Glutamine AND (meta-analysis OR systematic review)' and publications were retrieved, which provided quantitative statistical analysis of pooled treatment effects on the relative risks of infectious complications, mortality and length of stay in hospital. A total of 22 meta-analyses were entered into the current umbrella review. As displayed in Tables I, II and III, these analyses are split into three groups, based on different parameters. Of the 19 meta-analyses investigating the effects of infectious complications, 15 identified statistical...Continue Reading

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Citations

Sep 7, 2018·Experimental and Therapeutic Medicine·Xuefeng WangXiaohua He
Sep 1, 2017·JPEN. Journal of Parenteral and Enteral Nutrition·Douglas W Wilmore
May 2, 2020·Medizinische Klinik, Intensivmedizin und Notfallmedizin·F M BrunkhorstUNKNOWN Deutsche Sepsis Gesellschaft e. V.
Apr 4, 2021·Nutrients·Oliver ChenYiFang Chu
Jul 22, 2021·Food & Function·Rosângela Dos Santos FerreiraOctávio Luiz Franco
Aug 28, 2021·Nutrients·Aileen HillArved Weimann
Sep 6, 2018·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·George StavrouKaterina Kotzampassi

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