Therapeutic change of HMG-CoA reductase inhibitors in patients with coronary artery disease

Pharmacotherapy
D E HillemanT L Lenz

Abstract

To evaluate short-term outcomes when atorvastatin was substituted for pravastatin or simvastatin in patients with coronary artery disease. Open-label, fixed-dosage, one-way crossover from pravastatin and simvastatin to atorvastatin. University-affiliated hospital and outpatient clinics. Eighty patients with coronary artery disease with a minimum baseline low-density lipoprotein (LDL) above 130 mg/dl: 20 were treated with pravastatin 20 mg/day, 20 with pravastatin 40 mg/day, 20 with simvastatin 20 mg/day, and 20 with simvastatin 40 mg/day for a minimum of 6 months, with a prescription refill rate of 80% or greater. Intervention. Before crossover, patients had a fasting lipid profile determined and were questioned about side effects of pravastatin and simvastatin. All patients were switched to atorvastatin 10 mg/day. After 12 weeks of atorvastatin therapy, a repeat fasting lipid profile was obtained and patients were questioned about side effects with the drug. Baseline demographic and clinical characteristics of the treatment groups were not significantly different with the exception of a lower baseline LDL in patients receiving pravastatin 20 mg/day. Baseline LDL values were as follows: pravastatin 20 mg/day, 158+/-26 mg/dl; pr...Continue Reading

References

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Citations

Feb 4, 2003·Current Atherosclerosis Reports·Dean G Smith
Aug 10, 2013·International Psychogeriatrics·Gina BravoKaren Painter
May 1, 2008·Nature Clinical Practice. Rheumatology·Maarten Boers
Dec 8, 2004·Nature Medicine·Anne WoodEzekiel J Emanuel
Oct 20, 2005·SAR and QSAR in Environmental Research·E HulzebosL Maslankiewicz
May 1, 2007·Regenerative Medicine·Laure Brévignon-Dodin, Finbarr Livesey
Aug 18, 2004·International Journal of Clinical Practice·H Schuster
Jul 23, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·L A DonnellyP T Donnan
Feb 22, 2013·Journal of Food Science·Young-Su LeeSoo-Bok Lee
Apr 13, 2004·American Heart Journal·Herbert SchusterUNKNOWN Effective Reductions in Cholesterol Using Rosuvastatin Therapy I study group
Jun 10, 2004·The Annals of Pharmacotherapy·Michael G Kendrach, Maisha Kelly-Freeman

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