Therapeutic closure of the ductus arteriosus: benefits and limitations

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Isabelle MercantiU Simeoni

Abstract

Patency of the ductus arteriosus (PDA), a common complication of preterm birth, has been associated to increased risk for intraventricular cerebral hemorrhage, necrotizing enterocolitis, bronchopulmonary dysplasia and death. Consequently, prophylactic or curative treatment has been advocated before the critical left-to-right shunting occurs. A host of studies has shown that both pharmacological agents and surgical closure are effective in closing the ductus arteriosus in premature infants. Indomethacin has long been the drug of choice. However, renal and cerebral haemodynamic side effects have been frequently reported. Strategies to minimise adverse effects of indomethacin, such as the association with frusemide, dopamine or the use of low-dose prolonged treatment with indomethacin have failed or shown partial benefit. Other NSAIDs have been investigated. But either the profile of adverse effects was unfavourable, as in the case of mefenamic acid, or their efficacy was less than that of indomethacin for PDA closure. More recently, ibuprofen has been proposed for the treatment of PDA as it was shown to induce less adverse effects on cerebral blood flow, intestinal and renal hemodynamics, while retaining similar efficacy to indom...Continue Reading

References

Sep 1, 1991·American Journal of Diseases of Children·M D RellerR W McDonald
Jan 1, 1989·American Journal of Diseases of Children·A N KraussP A Auld
Oct 1, 1988·Paediatric and Perinatal Epidemiology·M van de BorJ H Ruys
Apr 1, 1995·The Journal of Pediatrics·M A RojasG Silva-Neto
Nov 1, 1996·Archives of Disease in Childhood. Fetal and Neonatal Edition·N Evans, M Kluckow
May 1, 1997·Archives of Disease in Childhood. Fetal and Neonatal Edition·B Van OvermeireK J Van Acker
Aug 31, 2001·Pediatric Surgery International·H NiinikoskiP Kero
May 30, 2003·Journal of Perinatology : Official Journal of the California Perinatal Association·Scott O GuthrieReese H Clark
Mar 17, 2004·Current Opinion in Pediatrics·Matthew M LaughonCarl L Bose
Dec 23, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·G NaulaersB Van Overmeire
Feb 9, 2005·Journal of Pediatric Gastroenterology and Nutrition·Shaul DollbergBrian Reichman
Feb 18, 2005·European Journal of Pediatrics·Ronald L ThomasJacob V Aranda
Apr 23, 2005·Archives of Disease in Childhood. Fetal and Neonatal Edition·J M BrooksK Simmer
Aug 23, 2005·Archives of Disease in Childhood. Fetal and Neonatal Edition·M El HajjarL Storme
Oct 8, 2005·Biology of the Neonate·Eduardo BancalariAlvaro Gonzalez
Dec 22, 2005·The Annals of Thoracic Surgery·Sophie JaillardLaurent Storme
Apr 21, 2006·Journal of Perinatology : Official Journal of the California Perinatal Association·E R Hermes-DeSantis, R I Clyman
Jun 14, 2006·Biology of the Neonate·Ronald I Clyman
Jan 11, 2007·Archives of Disease in Childhood. Fetal and Neonatal Edition·Sophie VanhaesebrouckClaire Theyskens
Feb 20, 2007·The Journal of Pediatrics·Nandkishor S KabraUNKNOWN Trial of Indomethacin Prophylaxis in Preterms Investigators
Apr 18, 2007·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·R P GinigerU Simeoni
May 8, 2007·Journal of Perinatal Medicine·David SweetUNKNOWN European Association of Perinatal Medicine

❮ Previous
Next ❯

Citations

Oct 13, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Franco BagnoliBarbara Tomasini
Jul 3, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·İrfan Oğuz ŞahinNaci Ceviz
Jun 19, 2014·British Journal of Clinical Pharmacology·Aline FuchsChantal Csajka
May 13, 2014·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·M López SousaM L Couce
Oct 8, 2016·Journal of Cardiothoracic Surgery·Mustafa Kemal AvsarCenap Zeybek
Dec 17, 2014·Open Journal of Cardiovascular Surgery·Gökhan AlbayrakEyup Hazan
Nov 27, 2019·Journal of Perinatology : Official Journal of the California Perinatal Association·Zachary CoffmanJason Buckley
Jun 4, 2020·Arquivos brasileiros de cardiologia·Walkiria Samuel AvilaTatiana de Carvalho Andreuci Torres Leal
Feb 28, 2021·Journal of Clinical Pharmacy and Therapeutics·Kannan SridharanAbdulraoof Al Madhoob
Jul 14, 2017·Pediatrics·Jana SemberovaZbynek Stranak

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
R P GinigerU Simeoni
The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG
James E Dice, Jatinder Bhatia
© 2022 Meta ULC. All rights reserved