Jul 1, 1977

Therapeutic comparison of thiol compounds in severe paracetamol poisoning

Annals of Clinical Biochemistry
A E SolomonR Birrell

Abstract

Twelve patients with toxic blood concentrations of paracetamol were treated with either cysteamine or amino-acid solution. None of the patients developed severe liver damage, although transient mild biochemical abnormalities developed in three. None of the patients treated with amino-acid solution had side effects due to therapy, whereas all those treated with cysteamine did. It is recommended that amino-acid solutions be used as a temporary measure in patients suspected of massive paracetamol overdose while awaiting estimation of blood paracetamol concentration.

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Mentioned in this Paper

Acetaminophen
Cysteamine
Sulfhydryl Compounds
Poisoning Aspects
Liver Damage
Brain Damage, Chronic
Acetaminophen Assay
Liver Function Tests
Substance-Related Disorders
Acamol

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