Therapeutic DNA vaccine against Trypanosoma cruzi infection in dogs

Annals of the New York Academy of Sciences
Israel Alejandro Quijano-HernandezEric Dumonteil

Abstract

Chagas' disease is an important health problem in most Latin American countries, and a concern in dog populations, which act as a reservoir. We showed in previous studies that a therapeutic DNA vaccine could partially control the pathology after Trypanosoma cruzi infection in mice, and this vaccine may represent an alternative treatment for Chagas' disease. Here we evaluated the therapeutic efficacy of this vaccine in experimentally infected dogs for up to 2 months after infection. Our results suggest that DNA vaccine treatment may affect the immune response and delay Chagas' disease progression in T. cruzi-infected dogs, and confirm the potential of this novel treatment.

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Citations

Oct 7, 2011·Vector Borne and Zoonotic Diseases·Olivia Rodríguez-MoralesMinerva Arce-Fonseca
Apr 13, 2012·Journal of Parasitology Research·Mauricio M RodriguesMaria Bellio
Nov 4, 2011·Human Vaccines·Israel Quijano-Hernandez, Eric Dumonteil
May 7, 2013·Acta Tropica·Alejandro Carabarin-LimaMinerva Arce-Fonseca
Feb 25, 2015·Nanomedicine·Maria Jose Morilla, Eder Lilia Romero
Jan 10, 2018·Infection and Immunity·Kathryn JonesMaria Elena Bottazzi
May 27, 2020·Journal of Immunology Research·Minerva Arce-FonsecaOlivia Rodríguez-Morales
Sep 13, 2019·Acta Tropica·Lizette E RiosNisha J Garg
Aug 19, 2021·Expert Review of Vaccines·Subhadip ChoudhuriNisha Jain Garg
Sep 4, 2021·PLoS Neglected Tropical Diseases·Leroy VersteegJeroen Pollet

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