PMID: 9631921Jun 19, 1998Paper

Therapeutic drug monitoring of alprazolam in adolescents with asthma

Therapeutic Drug Monitoring
C L DeVaneE J Antal

Abstract

Children and adolescents with severe asthma frequently experience anxiety or depression with anxiety, which can undermine their response to treatment. In addition, these patients often receive theophylline and a variety of adrenergic stimulants, which can exacerbate or worsen anxiety. Such children occasionally are candidates for treatment with anxiolytic therapy. There is a paucity of drug disposition data in adolescents for benzodiazepines, the most frequently used antianxiety drugs. The authors monitored the steady state alprazolam plasma concentration in six children with severe asthma who were administered standard doses of alprazolam. In one patient administered concurrent therapy with troleandomycin, a recognized cytochrome 3A4 inhibitor, alprazolam plasma concentration was markedly elevated. Overall, the disposition data of alprazolam was consistent with data previously reported in adults. Alprazolam appeared to be safe and effective for use in adolescents with asthma.

References

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Citations

Dec 14, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J L C M DorneA G Renwick
May 1, 2010·Expert Review of Clinical Pharmacology·Lindsey I SinclairAndrea L Malizia
Feb 11, 2009·The Journal of Allergy and Clinical Immunology·Antonio Dueñas-LaitaBlanca Martín-Armentia

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